Enhancement of Pulmonary Absorption of Fluorescein Isothiocyanate-Labelled Dextran (FITC-dextran) by Sodium Glycocholate in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of a sulfonic acid dye and a surfactant on the pulmonary absorption of fluorescein isothiocyanate-labelled dextran (FITC-dextran), a model macromolecular compound (MW=150000) which is not absorbed after pulmonary administration, were studied. Bromphenol blue, a sulfonic acid dye, did not show an enhancing effect. However, sodium glycocholate (SGC) considerably enhanced the pulmonary absorption of FITC-dextran. Therefore, SGC may be a useful additive to increase the systemic availability of macromolecular compounds administered as aerosol dosage forms.
- 社団法人日本薬学会の論文
- 1980-09-25
著者
-
高田 寛治
神戸女子薬科大学
-
山本 緑
神戸女子薬科大学
-
浅田 昌三
Kobe Women's College of Pharmacy
-
中江 裕子
Kobe Women's College Of Pharmacy
-
浅田 昌三
Kobe Women's College Of Pharmacy
関連論文
- インドメタシン多形の家兎消化管吸収による薬物速度論
- A Model Independent Approach to describe the Blood Disappearance Profile of intravenously Administered Drugs
- Enhancement of Pulmonary Absorption of Fluorescein Isothiocyanate-Labelled Dextran (FITC-dextran) by Sodium Glycocholate in Rats
- 薬学会役員選出方法に関する日米比較
- A Quantitative Structure-Activity Study of Anticonvulsant Phenylacetanilides
- Studies on Sustained-Release Dosage Forms. III. Preparation of Nifedipine Suppositories and Bioavailability in Rabbits
- Studies on Sustained-Release Dosage Forms. II. Pharmacokinetics after Rectal Administration of Indomethacin Suppositories in Rabbits
- Studies on Drug Nonequivalence. XI. Pharmacokinetics of 6-Mercaptopurine Polymorphs in Rabbits
- Studies on Drug Nonequivalence. X. Bioavailability of 6-Mercaptopurine Polymorphs
- Biopharmaceutical Study of the Hepatobiliary Transport of Drugs. VI. Inhibition of Active Biliary Excretion of Organic Cations by Retrograde Infusion
- 薬剤の非同等性に関する研究(第9報)インドメタシンの結晶多形と直腸吸収
- Comparative Pharmacokinetics of Acetohexamide and Its Metabolite, Hydroxyhexamide in Laboratory Animals
- Estimation of the Rates of Available Fraction for Some 4-Substituted Acetophenone Derivatives in the Rat : Reversible Drug-Metabolite Pharmacokinetics
- フロセミドのラットにおける体内動態に関するコンパートメントモデル解析の試み
- 医薬品の物理化学的性質(第3報)N_2-置換-N_1-arylsulfonylurea誘導体の分配係数および酸解離定数
- エテンザミドの家兎血漿中からの飽和過程を伴う消失に関する同時あてはめの適用
- INTERCONVERSION MODEL ANALYSIS AND ESTIMATION OF AVAILABLE FRACTIONS FOR 4-ACETAMINOBENZALDEHYDE AND ITS REVERSIBLE METABOLITE, 4-ACETAMINOBENZYLALCOHOL, IN THE RAT USING THE MULTI-LINES FITTING TECHNIQUE
- p-(±)-α-Hydroxyethylbenzenesulfonamide及びp-(±)-α-Hydroxyethylbenzenesulfonylurea誘導体のラット血漿中における酸化的代謝物
- ラットにおけるループ利尿剤, フロセミドおよびピレタニドの投与量依存性
- Synergistic Antiproliferative Effect of Interferons and Azidothymidine on HL60 Cells
- Reversible Pharmacokinetic Profiles of Canrenoic Acid and Its Biotransformed Product, Canrenone in the Rat
- ラットにおける同時あてはめを適用したアセトヘキサミドとその代謝物, ヒドロキシヘキサミドの相互変換モデル解析
- Interaction of Quinidine with Phospholipids. I. : Effect on Fluidity and Permeability of Phosphatidylcholine Vesicles
- Interaction of Theophylline with Bovine Serum Albumin and Competitive Displacement by Benzoic Acid
- 医薬品の物理化学的性質(第4報)消化管吸収シミュレーターにおけるバルビツール酸誘導体の透過性
- Statistical Study of the Model-independent Method to describe the Blood Disappearance Profile of Intravenously Administered Drugs
- Substituent Effects on the Alkaline Hydrolysis of 1-Methylbarbituric Acid Derivatives
- 愚案あれこれ(学会事業の在り方)
- 医薬品の物理化学的性質(第2報)Arylsulfonylurea誘導体の酸解離定数ろハメット則との関係
- イヌガヤCephalotaxus durpacea SIEB.et ZUCC.のアルカロイド
- Litsericineの構造 その2
- Litsericineの構造
- シロダモNeolitsea sericea(BLUME)KOIDZ.の樹皮部塩基 : クスノキ科植物アルカロイド研究(第5報)