医薬品の物理化学的性質(第3報)N_2-置換-N_1-arylsulfonylurea誘導体の分配係数および酸解離定数

概要

論文の詳細を見る
For thirty N_2-substituted-N_1-arylsulfonylurea derivatives (I), acid dissociation constants were determined by spectrophotomeric method, and the partition coefficients between water and carbon tetrachloride, cyclohexane, or chloroform were investigated systematically. 1. Distribution of the compounds is affected by the number of carbon atoms present and Taft's polar substituent constant of their N_2-substituent. 2. In respect to the effect of the aromatic substituent for the partition coefficient, it is presumed that the substituent constant π (Eq. 2) for a particular function is almost constant. 3. The Hammett-Taft linear re1ationship (Eq.6) was found to be estab1ished for the acid dissociation of these compounds.
公益社団法人日本薬学会の論文
1974-01-25