Interaction of Quinidine with Phospholipids. I. : Effect on Fluidity and Permeability of Phosphatidylcholine Vesicles
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概要
- 論文の詳細を見る
The effect of quinidine and its isomer, quinine, on the thermotropic behavior of phosphatidylcholine vesicles was studied by differential scanning calorimetry (DSC) and fluorescence polarization measurement. The effect on the release rates of carboxfluorescein and acrinol was also investigated. Quinidine and quinine lowered the lipid trasition temperatures and increased the release of the drugs contained in the lipid vesicles. This effect seems to be due to a fluidizing action on the membrane.
- 公益社団法人日本薬学会の論文
- 1986-05-25
著者
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浅田 昌三
Kobe Women's College of Pharmacy
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中江 裕子
Kobe Women's College Of Pharmacy
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浅田 昌三
Kobe Women's College Of Pharmacy
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