A Model Independent Approach to describe the Blood Disappearance Profile of intravenously Administered Drugs

概要

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A model independent approach is proposed to describe the blood disappearance profile of intravenously administered drugs. This approach requires a new definition of the total volume of distribution as a function of time. The total volume of distribution is regarded as the sum of V_1 and V_2. V_1 represents the initial volume of distribution after the intravenous administration of drugs. V_2 represents the additional distribution volume where the drug is distributed after the initial rapid distribution has ceased. To characterize V_2,two parameters, the maximum value of V_2,(V_2)_<max>, and the distribution constant, K_d, which is equal to the time when V_2 is equal to one-half its maximum, are adopted. It has been suggested by a simulation study that these two parameters, (V_2)_<max>, and K_d, are the major determinants of the rapid initial disappearance (i.e. distribution phase) of drugs from the blood stream after intravenous administration. The blood disappearance profile of warfarin was analyzed on the basis of this approach.
社団法人日本薬学会の論文
1981-05-23