ラットにおけるループ利尿剤, フロセミドおよびピレタニドの投与量依存性
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概要
- 論文の詳細を見る
Administrations of loop diuretic agents, furosemide and piretanide from the femoral vein and portal vein infusion of several doses to rats were carried out, and then, plasma concentrations and cumulative amounts excreted in the urine and bile of the drug were determined. The relationship between doses and the area under the plasma concentration-time curves (AUC) after intravenous administrations was nonlinear over the dose range from 10 to 30 mg/kg. Active renal excretion process was also supported, and then, it was observed that AUC's after intraportal infusion of each drug varied in accordance with alteration of infusion time in a dose of 10 mg/kg.
- 公益社団法人日本薬学会の論文
- 1982-11-25
著者
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山本 緑
神戸女子薬科大学
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中江 裕子
神戸女子薬科大学
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浅田 昌三
神戸女子薬科大学
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中江 裕子
Kobe Women's College Of Pharmacy
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浅田 昌三
Kobe Women's College Of Pharmacy
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乾 幸子
神戸女子薬科大学
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乾 幸子
Kobe Women's College Of Pharmacy
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