Studies on Drug Nonequivalence. VI. Physico-chemical Studies on Polymorphism of Acetohexamide
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概要
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Form I, form II, and CHCl_3-II type of acetohexamide are obtained by recrystallization from different solvents. X-ray diffraction patterns, infrared spectra, and differential scanning calorimeter curves of the CHCl_3-II type are identical with those of form II, but CHCl_3-II type contains a chloroform molecule, which cannot be removed by normal drying condition, and CHCl_3-II type seems unsuitable for medical use. The solubility of form II is 1.2 times that of form I.
- 社団法人日本薬学会の論文
- 1978-08-25
著者
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高岸 靖
塩野義製薬製造部
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高岸 靖
Production Division, Shionogi & Co., Ltd.
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梅田 常雄
Hospital pharmacy, Kobe University School of Medicine
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黒田 耕司
Hospital Pharmacy Kobe University School Of Medicine
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梅田 常雄
Hospital Pharmacy Kobe University School Of Medicine
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