SYNTHESIS AND BIOLOGICAL ACTIVITIES OF BIOISOSTERIC O-CARBA-ANALOGUES OF PLATELET ACTIVATING FACTOR (PAF)
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概要
- 論文の詳細を見る
Four types of O-carba-analogues of C_<16>-PAF were synthesized : d1-2-acetoxyeicosylphosphoryl choline (1), dl-3-hexadecyloxy-2-(2-oxopropyl) propylphosphoryl choline (2), d1-and (S)-(-)-3-acetoxy-4-hexa-decyloxybutylphosphonyl choline (3), and d1-2-acetoxy-3-hexadecyloxypropyl (3-trimethylammonio) propylphosphonate (4). Both in hypotension and in platelet aggregation, (S)-(-)-3 was one third as potent as synthetic C_<16>-PAF, whereas 1,2 and 4 were 100-3,000 times less potent.
- 社団法人日本薬学会の論文
- 1984-06-25
著者
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小池 博之
Biological Research
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Kobayashi S
Eisai Research Institute Of Boston Inc.
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中村 紀雄
Chemical Research Laboratories Sankyo Co., Ltd.
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宮崎 秀樹
Chemical Research Laboratories Sankyo Co., Ltd.
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大川 信幸
Chemical Research Laboratories Sankyo Co., Ltd.
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佐田 登志夫
Biological Research Laboratories Sankyo Co., Ltd.
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浅井 史敏
Biological Research Laboratories Sankyo Co., Ltd.
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小林 晋作
Biological Research Laboratories Sankyo Co., Ltd.
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小池 博之
Biological Research Laboratories Sankyo Co., Ltd.
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