A Synthesis of 2'-Acetyl-5,5', 6-trimethoxy-2-biphenylcarboxylic Acid.

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概要

• 論文の詳細を見る

• It has been found that the Friedel-Crafts reaction of 3-iodoanisole with acetyl chloride yielded, contrary to Oki's report, four products, 2'-hydroxy-4'-iodo-, 2'-iodo-4'-hydroxy, 2'-iodo-4'-methoxy-, and 2'-methoxy-4'-iodoacetophenone. The Ullmann condensation of 2'-iodo-4'-methoxyacetophenone with methyl 2-bromoor 2-iodo-veratrate, followed by hydrolysis, gave, in a poor yield, 2'-acetyl-5,5'6-trimethoxy-2-biphenylcarboxylic acid which was characterized as its oxime as well as its methyl ester.

• 公益社団法人日本薬学会の論文
• 1962-12-25

著者

• 小林 茂

  Kyowa Hakko Kogyo Co., Ltd., Tokyo Research Laboratories

• 小林 茂

  Pharmaceutical Faculty, University of Nagasaki

• 小林 茂

  Kyowa Hakko Kogyo Co. Ltd. Tokyo Research Laboratories

• 倉石 千鶴

  Pharmaceutical Faculty, University of Nagasaki

• 倉石 千鶴

  Pharmaceutical Faculty University Of Nagasaki

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• The Reimer-Tiemann Reaction of m-Halophenols. III. Formation of Dialdehydes
• The Reimer-Tiemann Reaction of m-Halophenols. II. With m-Bromophenol
• The Reimer-Tiemann Reaction of m-Iodophenol.
• A Synthesis of 2'-Acetyl-5,5', 6-trimethoxy-2-biphenylcarboxylic Acid.

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