Syntheses of Apogalanthamine Analogues as α-Adrenergic Blocking Agents. XII. : Syntheses and Stereochemistry of Methoxy and Methylenedioxy Derivatives of 8-Hydroxy-5,6,7,8-tetrahydrodibenz-[c, e]azocines
スポンサーリンク
概要
- 論文の詳細を見る
8-Hydroxy-5,6,7,8-tetrahydrodibenz[c, e]azocines 4b, c and their methoxy and methylenedioxy derivatives 7a-c and 8a-c were prepared by cyclization of O-protected 1-phenyl-2-aminoethanols 6b, c, 9a-c and 10a-c with zerovalent nickel, followed by hydrolysis of the resulting O-protected azocines 4d, e, 7d-f and 8d-f, respectively. The half-tub conformation of the tetrahydroazocine ring of these 8-hydroxydibenz[c, e]azocines and the quasi-equatorial configuration of the 8-hydroxy group were supported by the proton nuclear magnetic resonance spectra.
- 社団法人日本薬学会の論文
- 1989-04-25
著者
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小林 茂
Faculty Of Home Economics Shikoku University
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木原 勝
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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VANGVERAVONG Suwanna
Faculty of Pharmaceutical Sciences, The University of Tokushima
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大西 邦義
Faculty of Pharmaceutical Sciences, The University of Tokushima
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Vangveravong Suwanna
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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大西 邦義
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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