A Novel Method of Preparing Amine-Modifying C-4' Oxidized Nucleotide

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概要

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• A novel method of preparing C-4' oxidezed nucleotide, a monomeric model of an alkali labile lesion (1) has been studied. The C-4' selenated 4a and 4b were found to be effective in preparing 3,a monomeric model of 1,by the reaction with NBS (N-bromosuccinimide). The successive reaction of 3 with amine at room temperature afforded the α, β-unsaturated γ-methylene-γ-lactam (2) in good yield.

• 公益社団法人日本薬学会の論文
• 2000-09-01

著者

• SUEMUNE Hiroshi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• ASO Mariko

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Aso Mariko

  Graduate School Of Pharmaceutical Sciences Kyushu University

• RYUO Kazutoshi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• KONDO Mitsumasa

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Ryuo Kazutoshi

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Kondo Mitsumasa

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Suemune Hiroshi

  Graduate School Of Pharmaceutical Sciences Kyushu University

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