Modification of the Repair of Potentially Lethal Damage in Plateau-Phase Chinese Hamster Cells by 2-Chlorodeoxyadenosine

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概要

• 論文の詳細を見る

• The ability of 2-chlorodeoxyadenosine, a ribonucleotide reductase inhibitor, to inhibit the repair of potentially lethal damage was demonstrated in Chinese hamster V79 cells after X irradiation in plateau-phase cultures. This ability of the drug was completely diminished when deoxycytidine was added at the same time, though this was slightly affected by the addition of adenosine, suggesting that this drug was phosphorylated by deoxycytidine kinase to serve as an inhibitor of the repair of potentially lethal damage. Compared with hydroxyurea, another ribonucleotide reductase inhibitor, this drug appeared to contain its own activity which suppressed the repair of potentially lethal damage. A combined study of post-irradiation treatment with hypertonic salt solution and with this drug on the fixation of potentially lethal damage revealed that this drug inhibited the repair of hypertonicinsensitive potentially lethal damage.

• 日本放射線影響学会の論文

著者

• Matsuda A

  Hokkaido Univ. Sapporo Jpn

• Tanabe Kiyoshi

  富山医科薬科大学 放射線基礎医

• Sato F

  Japan Racing Assoc. Utsunomia

• Sato Fumiaki

  Faculty Of Veterinary Medicine Hokkaido Univ.

• MATSUDA Akira

  Faculty of Pharmaceutical Sciences, Hokkaido University

• UEDA TOHRU

  Faculty of Pharmaceutical Sciences, Hokkaido University

• KUWABARA Mikinori

  Faculty of Veterinary Medicine, Hokkaido University

• HIRAOKA Wakako

  Faculty of Veterinary Medicine, Hokkaido University

• TANABE KIYOSHI

  Faculty of Veterinary Medicine, Hokkaido University

• Matsuda Akira

  The Department Of Internal Medicine Kin-ikyo Chuo Hospital

• Sato F

  Equine Research Institute

• Ueda T

  Faculty Of Pharmaceutical Science Hokkaido University

• Hiraoka W

  Department Of Physics School Of Science And Technology Meiji University

• Sato F

  Hokkaido Univ. Sapporo

• Matsuda Akira

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Sato Fumiaki

  Faculty Of Information Shizuoka University

• Ueda Tohru

  Faculty Of Bioresource Sciences Akita Prefectural University

• Sato Fumiaki

  Faculty of Engineering, Shizuoka University

• TANABE Kiyoshi

  Dept. Radiol. Sci., Toyama Medical and Pharmaceutical Univ.

• TANABE Kiyoshi

  Department of Physics, Kagoshima University

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