Chemical Modification of Cytosine Residues of tRNA^<Val> with Hydrogen Sulfide (Nucleosides and Nucleotides. XL)
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概要
- 論文の詳細を見る
The conversion of cytosine residue of transfer ribonucleic acid (tRNA) to 4-thiouracil residues was carried out with a hydrogen sulfide-pyridine-water system. In the case of tRNA^<Val> from mouse cells, the cytosine moieties located in unpaired and looped-out regions of the molecule, such as the anticodon and CCA-end regions, were converted. This result shows that the secondary and tertiary structures of tRNA are maintained even in medium containing liquid hydrogen sulfide and pyridine, and hence, this system should be suitable for studies of the higher-order structure of nucleic acids.
- 公益社団法人日本薬学会の論文
- 1982-11-25
著者
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UEDA TOHRU
Faculty of Pharmaceutical Sciences, Hokkaido University
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Kato Nobuyuki
Virology Division National Cancer Center Research Institule
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Miura Kazunobu
Faculty Of Pharmaceutical Sciences Hokkaido University
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IWANO TATSUYOSHI
Faculty of Pharmaceutical Sciences, Hokkaido University
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TSUDA SHIGEKI
Faculty of Pharmaceutical Sciences, Hokkaido University
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HARADA FUMIO
Virology Division, National Cancer Center Research Institute
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Harada Fumio
Virology Division National Cancer Center Research Institute
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Ueda Tohru
Faculty Of Bioresource Sciences Akita Prefectural University
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Iwano Tatsuyoshi
Faculty Of Pharmaceutical Sciences Hokkaido University
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Tsuda Shigeki
Faculty Of Pharmaceutical Sciences Hokkaido University
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