Concentration of Metallothionein in Mice Livers after a Small Dose of Irradiation
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概要
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Metallothionein (MT), a low-molecular-weight protein, is induced in cultured cells and various animals by a variety of exogenous substances, including metals, organic solvents, and various agents, as well as by many kinds of physical stress such as UV or X irradiation, and injuries 1-3), MT is considered to be closely related to radioresistance in mice and rats irradiated with large doses of ionizing radiations because, although its activity in vivo is not clear, its scavenging activity is unusually efficient against free radicals in vitro. Koropatnick et al 4) found that MT accumulated in mice livers within 96 hours after cobalt-60 (^^60 Co) γ irradiation. Its accumulation peaked at 16-24 hours after irradiation. Changes in the MT concentration after a small dose (less than 1 Gy) of ionizing radiation, however, has not been investigated in detail, in such a case the MT concentration is expected to be slightly larger than or within normal limits. This study was made to determine whether MT is induced by a small dose (0.5 Gy) irradiation. B6C3F1/Nrs (C57BL/6J Nrs×C3H/He Nrs) mice of both sexes bred at the National Institute of Radiological Sciences (NIRS) (Inage, Japan), were housed under specific-pathogen-free (SPF) conditions, and used when 8-10 weeks old. One hundred mice of each sex were used in the sham study (unirradiated controls) and experimental (irradiated) groups. Eighty mice of each sex were given acute whole-body irradiation with ^^137 Cs γ-rays from a shield-type γ Cell irradiator (185 TBq in May 1971) (Toshiba Electric, Tokyo, Japan) at the NIRS under SPF conditions; two doses of 0.5 and 5.0 Gy given at 30 cm distant from the source, at the rate of 0.563 Gy/min. Twenty mice of each sex were used in the sham study. Every ten male and female mouse was killed by cervical dislocation on days 1, 7, 14, and 21 after irradiation. The same numbers of male and female control mice were killed on days 0 and 21. Livers were removed immediately after death then weighed and frozen in liquid nitrogen.
- 日本放射線影響学会の論文
著者
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MATSUMOTO Tsuneya
Institute for Environmental Sciences
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SATO Fumiaki
Department of Surgical Neurology Jichi Medical School
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Sato Fumiaki
Dept. Radiobiol. Inst. Environ. Sci.
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Noda Yuko
Division Of Biology And Oncology National Institute Of Radiological Sciences
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Yanai Takanori
Department of Life Science, Faculty of Science, Himeui Institute of Technology
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Otsu Hiroshi
国立環境研究所
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Otsu Hiroshi
Dept. Radiobiol. Inst. Environ. Sci.
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Sato F
Dept. Radiobiol. Inst. Environ. Sci.
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YANAI Takanori
Inst. for Environmental Sci.
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SAITOH MIKIO
Department of Radiobiology, Institute for Environmental Sciences
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HASEGAWA HIDENAO
Department of Radioecology, Institute for Environmental Sciences
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AKATA NAOFUMI
Tohoku Nuclear Co., Ltd.
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KANAIWA-KUDO SYOUKO
Tohoku Nuclear Co., Ltd.
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MATSUMOTO TSUNEYA
Section of Laboratory Animals and Plants, National Institute of Radiological Sciences
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OTSU HIROSHI
Department of Radiobiology, Institute for Environmental Sciences
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Saito Mikio
Dept. Radiobiol. Inst. Environ. Sci.
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Kanaiwa‐kudo S
Tohoku Nuclear Co. Ltd.
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Yanai Takanori
Department Of Biology Faculty Of Science Niigata University
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Sato F
Hokkaido Univ. Sapporo
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Akata Naofumi
Tohoku Nuclear Co. Ltd.
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Yanai T
Department Of Life Science Faculty Of Science Himeui Institute Of Technology
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Sato Fumiaki
Department Of Computational Intelligence And Systems Science Tokyo Institute Of Technology
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Hasegawa Hidenao
Department Of Radioecology Institute For Environmental Sciences
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Saitou Mikio
Department of Radiobiology, Institute for Environmental Sciences
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Sato Fumiaki
Department of Clinical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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