Transcription Factor-recognition Sequences Potentially Involved in Modulation of Gene Expression after Exposure to Low-dose-rate γ-rays in the Mouse Liver

スポンサーリンク

概要

• 論文の詳細を見る

• In vivo modulation of gene expression profiles after low-dose and low-dose-rate irradiation has been observed in a variety of experimental systems. However, few studies actually investigated the underlying mechanisms for these genetic responses. In this study, we used pre-existing microarray data and searched for gene modulations in response to long-term, low-dose-rate irradiation. Nucleotide sequences in the neighboring region of the up-regulated, down-regulated, and unaffected genes were retrieved from the Entrez Gene database, and recognition sequences for transcription factors (TFs) were searched using the TFSEARCH database. As a result, we suggested 21 potential TF-binding sites with significantly different incidence between the three gene groups (up-regulated, down-regulated and unaffected gene groups). The binding sites for sterol regulatory element-binding protein 1 (SREBP-1), aryl hydrocarbon receptor (AhR/Ar) and olfactory 1 (Olf-1) were suggested to be involved in up-regulation, while the binding sites for glucocorticoid receptor (GR(GGTACAANNT GTYCTK) ) and hepatocyte nuclear factor 1 (HNF-1) were suggested to be involved in down-regulation of the genes. In addition, the binding sites for activating enhancer-binding protein 4 (AP-4), nuclear factor-κB (NFκB), GR (NNNNNNCNNTNTGTNCTNN) and early growth response 3 (Egr-3) were correlated with modulation of gene expression regardless of the direction of modulation. Our results suggest that these TF-binding sites are involved in gene modulations after long-term continuous irradiation with low-dose-rate γ rays. GR and/or SREBP-1 might be associated with the altered metabolic process observed in liver after exposure to low-dose-rate irradiation.

• 2011-03-16

著者

• Tanaka Kimio

  Department Of Physics School Of Medicine Sapporo Medical University

• Ono Tetsuya

  東北大学 生命科学研究科

• Ono T

  Department Of Cell Biology Graduate School Of Medicine Tohoku University

• Tanaka Kimio

  Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences

• VARES Guillaume

  Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences

• UEHARA Yoshihiko

  Tohoku University, Graduate School of Medicine

• ONO Tetsuya

  Tohoku University, Graduate School of Medicine

• NAKAJIMA Tetsuo

  Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences

• WANG Bing

  Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences

• TAKI Keiko

  Clinical Genetic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research

• MATSUMOTO Tsuneya

  Institute for Environmental Sciences

• OGHISO Yoichi

  Institute for Environmental Sciences

• TANAKA Kimio

  Institute for Environmental Sciences

• ICHINOHE Kazuaki

  Institute for Environmental Sciences

• NAKAMURA Shingo

  Institute for Environmental Sciences

• TANAKA Satoshi

  Institute for Environmental Sciences

• NENOI Mitsuru

  Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences

• Vares Guillaume

  National Institute of Radiological Sciences

• Wang Bing

  National Institute of Radiological Sciences

• NENOI Mitsuru

  National Institute of Radiological Sciences

• Wang Bing

  Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences

• Tanaka K

  Department Of Physics School Of Medicine Sapporo Medical University

• Tanaka K

  Department Of Radiobiology Research Institute For Environmental Sciences

• Tanaka Kimio

  Dep. Of Radiobiology Inst. For Environmental Sciences

• Nakajima Tetsuo

  Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences

• Nakajima Tetsuo

  Radiat. Hazards Res. Group Nirs

• Oghiso Yoichi

  国立がんセンター研究所 がん予防基礎研究プロジェクト

• Oghiso Yoichi

  Internal Radiation Effects Research Group National Institute Of Radiological Sciences

• Wang B

  Research Center For Radiation Safety Natl. Inst. Radiol. Sci.

• Oghiso Yoichi

  Div. Radiotoxicol. Protect. Natl. Inst. Radiol. Sci.

• Ono Tetsuya

  Graduate School Of Medicine Tohoku Univ.

• Ono Tetsuya

  Tohoku Univ.

• Nenoi Mitsuru

  Radiat. Hazards Res. Gr. Natl. Inst. Radiol. Sci.

• Nenoi Mitsuru

  Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences

• Nakajima Tetsuo

  Radiat. Hazards Res. G. Nirs

• Nakajima Tetsuo

  Division Of Biology And Oncology National Institute Of Radiological Sciences

• Tanaka Kimio

  Dept. Of Cancer Cytogenet. Res. Inst. Rad. Biol. &med. Hiroshima University.

• Vares Guillaume

  (独)放射線医学総合研究所

• Uehara Yoshihiko

  Tohoku University Graduate School Of Medicine

• Wang Bing

  Univ. Tokyo School Of Sci. Zoological Institute

• Ono Takashi

  Research Center Of Health Physical Fitness And Sports Nagoya University

• Tanaka Kimio

  Res. Inst. Nuclear Med. Biol. Hiroshima Univ.

• Tanaka Satoshi

  Institute for Biosciences, Mukogawa Women's University

関連論文

• Inverse Dose-rate-effects on the Expressions of Extra-cellular Matrix-related Genes in Low-dose-rate γ-ray Irradiated Murine Cells
• Radiation Dose Measurement by Electron Spin Resonance Studies of Tooth Enamel in Lime and Non-lime Consuming Individuals from the Silchar Region of Northeast India
• Termisaltan Produced Regression of Left Ventricular Hypertrophy with the Improvement of Myocardial Perfusion and Fatty Acid Metabolism(Hypertension, Clinical 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Transcription Factor-recognition Sequences Potentially Involved in Modulation of Gene Expression after Exposure to Low-dose-rate γ-rays in the Mouse Liver
• Gene Silencing of Tead3 Abrogates Radiation-induced Adaptive Response in Cultured Mouse Limb Bud Cells
• Microdosimetry on a Mini-Reactor UTR-KINKI for Educational Uses and Biological Researches
• Microdosimetric Evaluation of Secondary Particles in a Phantom Produced by Carbon 290 MeV/nucleon Ions at HIMAC
• Effects of Sunlight Exposure on the Human Tooth Enamel ESR Spectra Used for Dose Reconstruction
• Coronary artery calcification detected by computed tomography is not related with angiographic stenosis grade for asymptomatic subjects
• Analysis of X-ray Induced Mutation in Ingeno Mouse and Its Problem
• Analysis of X-Ray-Induced Mutants in Muta^ Mouse
• In Vivo Assay of UV-induced Mutation in Mouse Skin
• Analysis of mutations associated with digestion of plasmid DNA with restriction enzymes
• Change of Mismatch-Specific Thymine DNA Glycosylase Acrivitiy in Mouse Liver in Aging Process
• Effects of 2.45 GHz Electro-Magnetic Field on Mutation in the lacZ-Transgenic Mouse
• PJ-036 Homogeneous washout pattern of 123I-MIBG images before beta-blocker therapy may predict the clinical outcome in patients with chronic heart failure(Nuclear Cardiology 2 (I) : PJ6)(Poster Session (Japanese))
• Mutation of RAS Oncogene in Atomic Bomb Radiation-exposed Leukemia
• Chromosomal Instability in Acute Myelocytic Leukemia and Myelodysplastic Syndrome Patients among Atomic Bomb Survivors
• Acute Myelogenous Leukemia With PIG-A Gene Mutation Evolved From Aplastic Anemia-Paroxysmal Nocturnal Hemoglobinuria Syndrome
• Microarray Analysis of Differentially Expressed Genes in the Kidneys and Testes of Mice after Long-term Irradiation with Low-dose-rate γ-rays
• Induction of Rhodanese, a Detoxification Enzyme, in Livers from Mice after Long-term Irradiation with Low-dose-rate Gamma-rays
• 66 Tissue specific mitochondrial DNA deletions in aged and irradiated mice(Radiation sensitivities in cells & tissues, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Miochondrial DNA Deletions and Aging induced by Low Dose Rate of Cs γ-ray in Mice
• Unstable-type Chromosome Aberrations in Lymphocytes from Individuals Living near Semipalatinsk Nuclear Test Site
• The Distribution and Retention of ^Sr in Mice after a Single Intravenous Injection of High and Low Doses
• Absence of Mutagenic Effects of 2.45GHz Radiofrequency Exposure in Spleen, Liver, Brain, and Testis of lacZ-Transgenic Mouse Exposed in Utero
• Dosimetry Evaluation of a Whole Body Exposure Setup for Small Animal at 2.45 GHz(Regular section)
• Retention excretion and translocation of Pu in rats following the Inhalation of PuO_2 fired at 400 and 1150t
• Dose-effect relationships of lung tumors induced by inhaled plutonium dioxide in the rat
• Dose dependence of lung tumors induced by inhaled plutonium dioxide in the rat
• Interactions between cytoskeletal components during myoplasm rearrangement in ascidian eggs
• Kinetics of Hematolymphoid Cells from Mice Injected with Plutonium
• Differential Dose Responses of Pulmonary Tumor Types in the Rat after Inhalation of Plutonium Dioxide Aerosols
• Cytogenetic and Molecular Changes in Leukemia among Atomic Bomb Survivors
• A gradient of radioactive contamination in Dolon village near the SNTS and comparison of computed dose values with instrumental estimates for the 29 August, 1949 nuclear test
• Validity of the Adaptive Filter for Accurate Measurement of Cardiac Output in Impedance Cardiography
• Comet Assay to Assess the Non-target Effect of Neutronradiation in Human Peripheral Blood
• Neutron-induced Adaptive Response Studied in Go Human Lymphocytes Using the Comet Assay
• High Incidence of Micronuclei in Lymphocytes from Residents of the Area near the Semipalatinsk Nuclear Explosion Test Site
• Neutron Energy-Dependent Initial DNA Damage and Chromosomal Exchange
• Chromosome aberrations and micronucleus in lymphocytes from residents of the area near the Semipalatinsknuclear explosion test site
• Chromosome and Micronucleus Aberrations in Lymphocytes from Resident Peoples in Semiparatinsk Nuclear Test Sites
• Chromosomal and Molecular Biological Changes in Atomic Bomb Radiation-related Leukemias, which were different from those in de novo Leukemias
• Nuclear Abnormalities in Aspirated Thyroid Cells and Chromosome Aberrations in Lymphocytes of Residents Near the Semipalatinsk Nuclear Test Site
• A cell based assay for low dose rate γ-ray radiation respone of murine cells
• 249 Prenatal Radiation-Induced Teratogenesis and Adaptive Response Modified by p53 and General Caspase Inhibitors(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Radiation-Induced Teratogenesis and Adaptive Response in the Late Period of Organogenesis in Mice : I. Dose Rate Effects
• Monosomy 7 and Jumping Translocation of ABL Oncogene in Radiation-induced Human Leukemias, detected by FISH Analysis
• ^Sr Concentration in Cow Teeth from South Ural Region, Russia, Using Monte Carlo Simulation
• The maintenance of genome integrity is tissue-specific
• Study on Influence of X-ray Baggage Scan on ESR Dosimetry for SNTS using Human Tooth Enamel
• X-ray-induced mutations in Muta^mouse
• Protein Expression of Cell Cycle Regulator, p27^, Correlates with Histopathological Grade of Non-Hodgkin's Lymphoma
• Instability of chromosome 7 in colony forming cells of patients with aplastic anemia
• Fluorescence in situ Hybridization Analysis of 12;21 Translocation in Japanese Childhood Acute Lymphoblastic Leukemia
• Detection of Residual Host Cells in Sex-mismatched Bone Marrow Transplantation in Various Hematological Diseases by Fluorescence in situ Hybridization
• Radiation Dose Estimation by Tooth Enamel EPR Dosimetry for Residents of Dolon and Bodene
• Results of EPR Dosimetry for Population in the Vicinity of the Most Contaminating Radioactive Fallout Trace After the First Nuclear Test in the Semipalatinsk Test Site
• Tooth Enamel EPR Dosimetry : Optimization of EPR Spectra Recording Parameters and Effect of Sample Mass on Spectral Sensitivity
• Hidden genetic or chromosomal alterations in patients with acute myeloid leukemia showing a cytogenetically normal karyotype
• Beat-to-Beat Evaluation of Systolic Time Intervals during Bicycle Exercise Using Impedance Cardiography
• S-3-5 Late effects of long-term low-dose-rate irradiated mice(Biological Effects of Low Dose and Low Dose-rate Irradiations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Long-term Low-dose-rate Continuous Gamma-ray Irradiation on Mice -interim report 2-
• Long-term Low-dose-rate Continuous Gamma-ray Irradiation on Mice : interim report
• Concentration of Metallothionein in Mice Livers after a Small Dose of Irradiation
• Evaluation of Shared DRAM for Parallel Processor System with Shared Memory (Special Section on VLSI Design and CAD Algorithms)
• Effects of Caspase Inhibitors on Nuclear Protein NP95 Depletion Associated with Radiation-induced Apoptosis in Murine ThymicLymphoma 3SB Cells.
• X-ray-induced somatlc mutatlon in mouse liver
• Involvement of Ubiquitin-Activating System in DNA Repair in Mammalian Cells
• 8 Profiling of low-dose-rate γ-rays irradiation on the gene expression in murine cells by microarray(Low dose and low dose-rate effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Effect of 0.5 Gy Pre-expore on the PFC of Lethally Irradiated Mice
• Fas-independent Apoptosis Induced by UVC in p53-Mutated Human Epithelial Tumor A431 Cells through Activation of Caspase-8 and JNK/SAPK
• Radioadaptation in Embryogenesis during Late Period of Organogenesis and Postnatal Retardation in the Prenatally Primed Mice
• RELATIONSHIP OF ACCESSORY PATHWAY CONDUCTION TO THE ATRIAL VULNERABILITY IN WOLFF-PARKINSON-WHITE SYNDROME: COMPARISON BEFORE AND AFTER CATHETER ABLATION
• USEFULNESS OF INTRACARDIAC ELECTROGRAM RECORDINGS FOR DIAGNOSIS OF SINUS NODE FUNCTIONS IN SSS PATIENTS AND FOR ABLATION OF WPW SYNDROME AND ARIOVENTRICULAR NODE REENTRY TACHYCARDIA
• P-10. Dose and dose-rate effects on dicentrics and translocations in mice spleen cells after continuous irradiation with low-dose-rate gamma-rays(Abstracts for the oral and the poster presentations,Abstracts of the Joint Meeting: the 58th Annual Meeting o
• A New Method for improving Information Bit Rate and Average Bit Error Rate in Two Way Transmission Systems
• γ and α ray induced delayed chromosome instability in human B cell line
• Induction of Delayed Chromosome Instability in Human Hematopoietic Cells by Various Radiation Sources
• Detection of 9;22 translocation and monosomy 7 on interphase cells in atomic bomb related leukemias by fluorescence in situ bybridization
• Frequencies of ^Co γ rays and ^Cf neutron-induced chromosome translocations in human lymphocytes, detected by two colors fluorescence in situ hybridization of chromosome subsets.
• Positive and Negative Regulation of Radiation-induced Apoptosis by Protein Kinase C
• Design of the Transmission Line Simulator having a Certain Bit Error Rate ((放送方式、放送現業、無線・光伝送)2000 Asia-Pacific Symposium on Broadcasting and Communications)
• Statistical Propagation Characteristics for Land-Mobile Satellite Communication
• A Method for increasing Information Bit Error Rate and decreasing Delay Time in Burst Transfer System and Its Performance Evaluation(ABSTRACTS OF PROCEEDINGS OF THE SCHOOL OF INFORMATION TECHNOLOGY AND ELECTRONICS SERIES J TOKAI UNIVERSITY -2003-2004-)
• The Expression of the Protochordate Homologue of the Proteasome Regulatory Subunit Rpn12 is Transcriptionally and Post-translationally Regulated during Cleavage Stage(Developmental Biology)
• An alternatively spliced gene encoding a Y-box protein showing maternal expression and tissue-specific zygotic expression in the ascidian embryo
• Two Distinct Cell Types Identified in the Ascidian Notochord
• Involvement of Ubiquitin-Conjugating System in DNA Repair in Mammalian Cells
• 60 Energy Spectrum Dependent Chromosome Aberrations in Monoenergetic Neutrons(Chromosome aberrations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Design of Parallel Scrambler Applied to Digital Multiplexer
• In Vivo Assay for UV-induced Mutation with Muta^ Mouse
• Improvement of Assay System for Radiation-Induced Mutation Frequency using Muta^-Mouse
• Gene Silencing of Tead3 Abrogates Radiation-induced Adaptive Response in Cultured Mouse Limb Bud Cells
• Transcription Factor-recognition Sequences Potentially Involved in Modulation of Gene Expression after Exposure to Low-dose-rate γ-rays in the Mouse Liver
• Formation and Repair of Psoralen Cross-Links In Vivo Analyzed at Nucleotide Resolution
• The comparison of dose distributions in a water phantom for accelerator-based and reactor-based neutron irradiation fields for NCT.
• A Consideration about Neutron Irradiation Systems for Boron Neutron Capture Therapy using Accelerators and Research Reactors
• Trp53 Activity Is Repressed in Radio-adapted Cultured Murine Limb Bud Cells
• Alteration of Genome Structure Induced by Very Low Dose-Rate Irradiation in Mouse Tissues

もっと見る 閉じる

スポンサーリンク