Alteration of Genome Structure Induced by Very Low Dose-Rate Irradiation in Mouse Tissues
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概要
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To understand the effects of low dose-rate radiation on genome structure in vivo, we examined gene mutation and chromosomal abnormality in mouse tissues. The mutation was studied on transgenes in the spleen and liver and also on the Dlb1 gene in intestinal stem cells. The mice were irradiated for 483 consecutive days at three dose-rates of 0.0323, 0.65, and 12.5 ?Gy/min, which resulted in total doses of 21, 414, and 8,000 mGy, respectively. Statistically significant increases were observed for all indices examined when the total dose was 8,000 mGy, whereas no significant difference was observed with 21 mGy or 414 mGy.
著者
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MATSUMOTO Tsuneya
Institute for Environmental Sciences
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OGHISO Yoichi
Institute for Environmental Sciences
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TANAKA Kimio
Institute for Environmental Sciences
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ICHINOHE Kazuaki
Institute for Environmental Sciences
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NAKAMURA Shingo
Institute for Environmental Sciences
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TANAKA Satoshi
Institute for Environmental Sciences
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YOSHIDA Mitsuaki
National Institute of Radiological Science
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Fujikawa Kazuo
Faculty Of Science And Engineering Kinki University
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Tanaka Satoshi
Institute for Biosciences, Mukogawa Women's University
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Ono Tetsuya
Dept of Cell Biology, Tohoku University Graduate School of Medicine
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Hayata Isamu
National Institute of Radiological Science
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Nohmi Takehiko
National Institute of Health Science
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Uehara Yoshihiko
Dept of Cell Biology, Tohoku University Graduate School of Medicine
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Okudaira Naohito
Dept of Cell Biology, Tohoku University Graduate School of Medicine
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Kagawa Nao
Faculty of Science and Technology, Kinki University
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