Dose-effect Relationship of Dicentric and Ring Chromosomes in Lymphocytes of Individuals Living in the High Background Radiation Areas in China
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概要
- 論文の詳細を見る
Chromosomes of 39 healthy family members (3 generations from 13 families) living both in the highlevel background radiation areas (HBRA) and the control areas (CA) were studied. Cumulative dose from birth to the time of blood sampling was estimated by calculating measured exposure rate in each individual. The cumulative doses ranged 30.9-358.9 and 6.0-59.2 mGy for HBRA and CA, respectively. Peripheral lymphocyte chromosome preparations were made according to our improved method. Dicentric and ring chromosomes (Dic+Rc) were scored in average 2,527 cells per individual in HBRA and 2,694 cells in CA under a microscope equipped with an automated stage. A positive correlation between Dic+Rc and age was found in HBRA, while no such dose relationship was clear in CA. The frequency of Dic+Rc linearly increases over lifetime due to chronic low dose exposure and it is likely that the activation of repair enzymes is not triggered in the present HBRA. Threshold dose (rate) of the induction of chromosome aberrations, if any, is below the present dose (rate) level.
- 日本放射線影響学会の論文
著者
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HAYATA Isamu
National Institute of Radiological Sciences
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SUGAHARA Tsutomu
Health Res. Fond.
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Jiang Tao
Laboratory Of Industrial Hygiene Ministry Of Health
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Wang Chunyan
National Institute For Radiological Protection Chinese Center For Disease Control And Prevention
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Yuan Y
Labor Hygiene Institute Of Hunan Province
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Yuan Yongling
Labor Hygiene Institute Of Hunan Province
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WANG CHUNYAN
Laboratory of Industrial Hygiene, Ministry of Health
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CHEN DEQING
Laboratory of Industrial Hygiene, Ministry of Health
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WEI LUXIN
Laboratory of Industrial Hygiene, Ministry of Health
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Wei Luxin
National Institute For Radiological Protection Chinese Center For Disease Control And Prevention
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Wei Lexin
中華人民共和国
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Wei Luxin
Laboratory Of Industrial Hygiene Ministry Of Health
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Yao Suyan
Laboratory Of Industrial Hygiene Ministry Of Health
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Chen Deqing
National Institute For Radiological Protection Chinese Center For Disease Control And Prevention
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Liu Qingjie
Laboratory Of Industrial Hygiene Ministry Of Health
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Hayata I
Natl. Inst. Radiol. Sci.:cent. Res. Inst. Elec. Pow. Ind.
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Sugahara Tsutomu
Laboratory Of Industrial Hygiene Ministry Of Health
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NAKAI SAYAKA
Health Research Foundation
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DAI LIANLIAN
Laboratory of Industrial Hygiene, Ministry of Health
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Dai Lianlian
Laboratory Of Industrial Hygiene Ministry Of Health
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Wei Luxin
Chinese Natl. Inst. Radiol. Prot. Nucl. Saf.
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Hayata Isamu
National Institute of Radiological Science
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