A Case-control Study of Nasopharyngeal Carcinoma in the High Background Radiation Areas of Yangjiang, China
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概要
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The main purposes of this study were to identify the major determinants of nasopharyngeal carcinoma (NPC) in the high-background radiation areas (HBRA) in Yangjiang, China and to evaluate their potential confounding effects on the NPC risk associated with exposure to high background radiation. A matched case-control study was conducted using those who died of NPC during the period 1987-1995. Two controls were randomly selected for each case from those who died from causes other than malignancies and external causes. Cases and their controls were matched with respect to sex and the years of birth and death (±5 years). Study subjects'next-of-kin were interviewed using a standardized questionnaire to collect information on socioeconomic status, dietary habits, tobacco smoking and alcohol consumption, disease history, pesticide use, medical X-ray exposure, the family history of NPC and so on. We succeeded in interviewing 97 cases and 192 controls. Univariate conditional logistic regression analysis showed that NPC risk was associated with the consumption of salted fish, homemade pickles, and fermented soy beans, education levels, the history of chronic rhinitis, and the family history of NPC. Multivariate conditional logistic regression analysis revealed that education levels (Odds ratio (OR) for middle school or higher levels vs. no school education = 3.8 , 95% CI = 1.2 to 11.8), salted fish intake (OR = 3.2, 95% CI = 1.7 to 6.1), the history of chronic rhinitis (OR = 3.6, 95% CI = 1.3 to 10.1), and the family history of NPC (OR = 14.2, 95% CI = 2.7 to 73.4) were independent risk factors of NPC. Tobacco smoking (OR = 1.2, 95% CI = 0.7 to 2.1), and alcohol consumption (OR = 0.9, 95% CI = 0.5 to 1.9) were not significantly related to NPC risk. The ORs of NPC risk comparing HBRA and a nearby control area before and after adjustment for the major risk determinants identified in the present study were 0.86 (95% CI = 0.50 to1.50) and 0.87 (95% CI = 0.45 to1.67), respectively. Salted fish intake was a strong risk factor of NPC. Education, the history of chronic rhinitis and the family history of NPC were also related to NPC risk. The exposure to high background radiation in HBRA of Yangjiang was not related to NPC risk with or without the adjustment for those major risk determinants of NPC.
- 日本放射線影響学会の論文
著者
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AKIBA Suminori
Department of Epidemiology and Preventive Medicine, Kagoshima University, Graduate School of Medical
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Yuan Y
Labor Hygiene Institute Of Hunan Province
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Akiba Suminori
Department Of Public Health Faculty Of Medicine Kagoshima University
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Akiba Suminori
Department Of Epidemiology And Preventive Medicine Kagoshima University Graduate School Of Medical A
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Yuan Yongling
Labor Hygiene Institute Of Hunan Province
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WEI LUXIN
Laboratory of Industrial Hygiene, Ministry of Health
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Wei Luxin
National Institute For Radiological Protection Chinese Center For Disease Control And Prevention
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Wei Lexin
中華人民共和国
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Wei Luxin
Laboratory Of Industrial Hygiene Ministry Of Health
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Zou Jianming
Guangdong Institute Of Prevention And Treatment Of Occupational Diseases
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Zha Yongru
Guangdong Institute Of Prevention And Treatment Of Occupational Diseases
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Sugahara Tsutomu
Laboratory Of Industrial Hygiene Ministry Of Health
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TAO ZUFAN
Laboratory of Industrial Hygiene, Ministry of Health
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SUN QUANFU
Laboratory of Industrial Hygiene, Ministry of Health
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ZHA YONGRU
Health Research Foundation
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TAO ZUFAN
Guangdong Institute of Prevention and Treatment of Occupational Diseases
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Tao Zufan
Laboratory Of Industrial Hygiene Ministry Of Health
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Sun Quanfu
Laboratory Of Industrial Hygiene Ministry Of Health
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Wei Luxin
Chinese Natl. Inst. Radiol. Prot. Nucl. Saf.
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