PULMONARY DEPOSITION AND EFFECTS OF INHALED SILICA PARTICLES AFTER SHORT-TERM EXPOSURES IN THE RAT
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概要
- 論文の詳細を見る
The present study was designed to evaluate the pulmonary deposition and the effects of inhaled silica particles in the rat model. Wistar (W/M strain) rats were exposed to silica aerosols generated from a fluidized bed dust generator for 1 hr a day, intermittently for 6 days, using a "nose-only" inhalation chamber. After the cessation of the exposures, analysis of lavaged bronchoalveolar cells (BAC) and histological examinations of lungs and tracheobronchial lymph nodes (TBLN) were performed during a period of 6 months. Total cell yields and the proportions of alveolar macrophages (AM) in BAC were not altered, whereas the proportions of lymphocytes in BAC were significantly increased in the exposed animals. Although the proportions of silicaladen AM in BAC were gradually decreased during the 6 months, particle-laden AM were predominantly and persistently observed in the alveoli under light microscopy. Silica particles were also identified in macrophages of granulomatous nodules in pulmonary peribronchial lymphoid tissues (PBLT) and TBLN, indicating the translocation of particles via the lymph. Associated with pulmonary particle deposition, some characteristic histopathological features were evident, including thickening of alveolar duct bifurcations and lymphocyte infiltrations both in the alveolar sacs and around the interstitial blood vessels. At later months after the exposures, the alveolar interstitium was thickened with the increase of fibroblasts and collagen. These results implicate that short-term exposures of silica particles in the rat can evoke histopathologic changes in the lungs and lymphatic tissues, associated with their deposition and translocation.
- 日本トキシコロジー学会の論文
- 1986-02-25
著者
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Yamada Yuji
Division Of Urology Department Of Organ Therapeutics Kobe University Graduate School Of Medicine
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MATSUOKA Osamu
Division of Radiation Hazards National Institute of Radiological Sciences
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OGHISO Yoichi
Institute for Environmental Sciences
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Yamada Y
National Inst. Radiological Sci. Chiba Jpn
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Yamada Yutaka
国立がんセンター研究所 がん予防基礎研究プロジェクト
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Matsuoka O
National Inst. Radiological Sciences Chiba‐shi Jpn
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KUBOTA Yoshihisa
Division of Comparative Radiotoxicology, National Institute of Radiological Science
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Kubota Yoshihisa
Div. Environmental And Toxicological Res. Group Research Center For Radiation Safety National Instit
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Kubota Yoshihisa
Division Of Comparative Radiotoxicology National Institute Of Radiological Sciences
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OGHISO YOICHI
Division of Comparative Radiotoxicology, National Institute of Radiological Sciences
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Oghiso Y
National Inst. Of Radiological Sci. Chiba Jpn
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Oghiso Yoichi
Internal Radiation Effects Research Group National Institute Of Radiological Sciences
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Matsuoka Osamu
Mitsui Chemicals Inc.
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Oghiso Yoichi
Div. Radiotoxicol. Protect. Natl. Inst. Radiol. Sci.
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Yamada Yuji
National Inst. Radiological Sci. Chiba Jpn
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Matsuoka Osamu
Division Of Comparative Radiotoxicology National Institute Of Radiological Sciences
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Yamada Yuji
Division Of Radiotoxicology And Protection
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Yamada Yuji
Division Of Multidisciplinary Radiotherapy Osaka University Graduate School Of Medicine
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MATSUOKA Osamu
Laboratory of Applied Physics, The University of Electro-Communications
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