The Distribution and Retention of ^<89>Sr in Mice after a Single Intravenous Injection of High and Low Doses

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Female C3H/He mice, aged 12-17 weeks, were injected intravenously with ^<89>SrCl2 at doses of 0.74kBq g-1 body weight (low dose) or 74.0kBq g-1 (high dose). During the first week after injection, approximately 45% of the injected ^<89>Sr was excreted in the urine and feces in both dose groups. The excretion of ^<89>Sr decreased thereafter. The total excretion up to 56 days after injection was 63.0% and 64.5% of the injected dose in the high and low dose groups, respectively. There was no significant difference in the excretion of ^<89>Sr in the urine between the two groups, while the fecal excretion in the low dose group was slightly higher than in the high dose group. The retention of ^<89>Sr in the right and left femurs was 1.30 and 1.46% of the injected dose on day 7, which decreased to 0.64 and 0.70% on day 56, in the high and low dose groups, respectively. No significant difference was observed in bone retention of ^<89>Sr between the two groups. The amount of 89Sr distributed to the soft tissues was very small and became undetectable by 42 days after injection.
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