Isolichenan, an α-glucan isolated from lichen Cetrariella islandica, repaires impaired learning behaviors and facilitates hippocampal synaptic plasticity
スポンサーリンク
概要
- 論文の詳細を見る
The acute effects of isolichenan, a homologous α-glucan (1-3)(1-4) (3:2) isolated from lichen Cetrariella islandica, on the hippocampal synaptic plasticity were investigated in rats in vivo. Isolichenan (1mg /kg, intravenous treatment) significantly enhanced short-term potentiation evoked by a subthreshold tetanus, without any effect on the basal synaptic excitability (no tetanus stimulation). No effects on a supra-threshold tetanus-evoked potentiation were found. Isolichenan did not influence learning behaviors of intact mice in passive-avoidance tests and of intact rats in the Morris water maze test. When the learning ability of mice was impaired by 30% ethanol pre-treatment, isolichenan (>100mg/kg, oral treatment) significantly improved memory acquisition in passive-avoidance tests. Similarly, isolichenan (100 mg/kg, oral treatment) repaired memory-impairment induced by β-amyloid peptide (fraction 25-35) in the Morris water maze test in rats. These results suggest positive effects of isolichenan on spatial memory formation in rodents.
- 日本学士院の論文
著者
-
SHIBATA Shoji
Shibata Laboratory of Natural Medicinal Materials, c
-
Shibata Shoji
Shibata Laboratory Of Natural Medicinal Materials
-
CHEN Ji
Institute of sports Medicine Beijing Medical university
-
ZHANG Jun-Tian
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
-
Chen Ji
Institute Of Materia Medica Chinese Academy Of Medical Sciences And Peking Union Medical College
-
Zhang Jun-tian
Institute Of Materia Medica Chinese Academy Of Medical Sciences And Peking Union Medical College
-
NARUI Takao
Meiji Pharmaceutical University
-
Smriga Miro
Ajinomoto Co., Inc. ; Central Res. Labs.
-
HIRANO Eiko
Nihon University, College of Pharmacy
-
SAITO Hiroshi
Nihon University, College of Pharmacy
-
SMRIGA Miro
Ajinomoto Co., Inc., Central Research Laboratories
-
SHIBATA Shoji
Shibata Laboratories of Natural Medicinal Materials, c/o Minophagen Pharmaceutical Co. Ltd.
-
CHEN Ji
Institute of Materia Medica, Chinese Academy of Medical Sciences
関連論文
- Inhibitory Effect of Chalcone Derivatives on Recombinant Human Aldose Reductase
- Antitumorigenic Activities of Chalcones (II). Photo-isomerization of Chalcones and the Correlation with Their Biological Activities
- Inhibitory Effect of Glycyrrhetinic Acid Derivatives on Capsaicin-Induced Ear Edema in Mice
- Environmental and Genetic Factors of Hyperlipidemia in Athletes and Coaches(招待講演) (第49回日本体力医学会大会)
- Improvement of Memory in Mice and Increase of Hippocampal Excitability in Rats by Ginsenoside Rg1's Metabolites Ginsenoside Rh1 and Protopanaxatriol
- Identification of the licorice root stored in Shosoin based on the sequences of internal transcribed spacer (ITS) on nrDNA and the chemotaxonomic consideration
- β_1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo
- Further Studies on the Structure of Polysaccharides from the Lichen Flavoparmelia caperata (L.) HALE
- 1999年度日本味と匂学会第33回大会
- 1999年度日本味と匂学会第33回大会
- Anti-Blood Coagulation and Cytotoxic Effects of Compounds from Chinese Plants Used for Thrombosis-Like Diseases
- Isolichenan, an α-glucan isolated from lichen Cetrariella islandica, repaires impaired learning behaviors and facilitates hippocampal synaptic plasticity
- Antioxidant activity of red pigments from the lichens Lethariella sernanderi, L. cashmeriana, and L. sinensis
- Bryoria hengduanensis (Lichenized Ascomycota, Parmeliaceae), a New Species from Southern China
- Anti-Blood Coagulation and Cytotoxic Effects of Compounds from Chinese Plants Used for Thrombosis-Like Diseases
- A Drug over the Millennia : Pharmacognosy, Chemistry, and Pharmacology of Licorice
- Long-Term Ingestion of Monosodium L-Glutamate Did Not Induce Obesity, Dyslipidemia or Insulin Resistance: A Two-Generation Study in Mice