Inhibitory Effect of Traditional Turkish Folk Medicines on Aldose Reductase (AR) and Hematological Activity, and on AR Inhibitory Activity of Quercetin-3-O-methyl Ether Isolated from Cistus laurifolius L.(Pharmacognosy)

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概要

• 論文の詳細を見る

• The inhibitory effects of 40 extracts prepared from 38 traditional Turkish folk medicines on human aldose reductase (h-AR) and hematological activity were investigated. Seven plants containing 5 species of Cistus genus exhibited a potent inhibition of h-AR. Femlago amani (root) inhibited the platelet aggregation induced by sodium arachidonate, while C. laurifolius (fruit) was found to possess strong inhibition in the blood coagulation assay. An AcOEt extract derived from the leaf of C. laurifolius was purified to isolate three known flavonoids. The activity of one, quercetin-3-O-methyl ether, was found to be as potent as that of eparlestat, which is known to be a remedy for treating complications associated with diabetes.

• 公益社団法人日本薬学会の論文
• 2004-07-01

著者

• OKUYAMA Toru

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• OKADA Yoshihito

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• Okada Y

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Okuyama Toru

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Okuyama T

  Department Of Natural Medicine & Phytochemistry Meiji Pharmaceutical University

• Coskun Maksut

  Department Of Pharmaceutical Botany Faculty Of Pharmacy Ankara University

• Erdurak Ceyda

  Faculty Of Pharmacy Ankara University

• ENOMOTO Shigeki

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• GUVENC Aysegul

  Faculty of Pharmacy, Ankara University

• COSKUN Maskut

  Faculty of Pharmacy, Ankara University

• Guvenc Aysegul

  Faculty Of Pharmacy Ankara University

• Okada Yoshihito

  Department Of Pharmacognosy And Phytochemistry Meiji College Of Pharmacy

• Ogino Yoshio

  The Third Department Of Internal Medicine Yeikyo University School Of Medicine

• Enomoto Shigeki

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Okuyama Toru

  Meiji Pharmaceutical Univ. Tokyo Jpn

• Okada Yoshihito

  Department Of Natural Medicine And Phytochemistry Meiji Pharmaceutical University

• Ogino Y

  Teikyo Univ. School Of Medicine Chiba

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