Inhibitory Effects of Herbal Extracts on the Activity of Human Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3)(Biopharmacy)
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概要
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Sulfotransferase 1A3 (SULT1A3) is a phase II detoxifying enzyme of xenobiotics predominantly expressed in the intestinal epithelium. Recent increase in the use of herbal extracts as dietary supplements may lead to an increase in the possibility of dietary supplement-drug interactions. The purpose of the present study was to investigate the effects of 18 herbal extracts on SULT1A3 activity and the possibility of interaction between medicinal drugs and herbal extracts. We examined the inhibitory potencies of 18 herbal extracts on the sulfation of dopamine, a typical substrate of SULT1A3, and ritodrine, a β_2 stimulant, by human recombinant SULT1A3. The sulfation of dopamine was inhibited by extracts of banaba, green tea, Rafuma, grape seed, peanut seed coat, gingko biloba leaf, St. John's wort, gymnema and milkthistle. The IC_<50> values of these herbal extracts were lower than the putative gastrointestinal concentration when the recommended dose was ingested. On the other hand, chlorella extract and rutin showed no inhibitory effects and wheat, mulberry and siberian ginseng had IC_<50> values exceedingly higher than the putative gastrointestinal concentration. The inhibitory profiles of herbal extracts for the sulfation of ritodrine were comparable to those for the sulfation of dopamine. In conclusion, the extracts of herbs such as banaba and green tea potently inhibited SULT1A3 activity. These extracts may increase the bioavailability of drugs whose bioavailabilities were limited by the function of SULT1A3 on the intestinal epithelium.
- 社団法人日本薬学会の論文
- 2009-01-01
著者
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Hiratsuka Akira
Department Of Drug Metabolism And Molecular Toxicology Tokyo University Of Pharmacy And Life Science
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OGURA KENICHIRO
Department of Drug Metabolism and Molecular Toxicology, Tokyo University of Pharmacy and Life Scienc
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TSUJIMOTO Masayuki
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
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OHTANI Hisakazu
Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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SAWADA Yasufumi
Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Sawada Y
Department Of Pharmaceutics Graduate School Of Pharmacertical Sciences Kyushu University
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Sawada Yasufumi
Laboratory Of Drug Informatics Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Hiratsuka Akira
Department Of Drug Metabolism And Molecular Toxicology School Of Pharmacy Tokyo University Of Pharma
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Hiratsuka Akira
Department Of Biology Faculty Of Science Tohoku University
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NAGAI Marie
Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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FUKAMACHI Takahiro
Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu Uni
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HORI Satoko
Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Nagai Marie
Laboratory Of Drug Informatics Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Hori Satoko
Laboratory Of Drug Informatics Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Ogura Kenichiro
Department Of Drug Metabolism And Molecular Toxicology School Of Pharmacy Tokyo University Of Pharma
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Fukamachi Takahiro
Department Of Medico-pharmaceutical Sciences Graduate School Of Pharmaceutical Sciences Kyushu Unive
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Ohtani Hisakazu
Laboratory Of Drug Informatics Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Tsujimoto Masayuki
Department Of Medico-pharmaceutical Sciences Graduate School Of Pharmaceutical Sciences Kyushu Unive
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Tsujimoto Masayuki
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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