mRNA Expression of the ATP-Binding Cassette Transporter Subfamily A (ABCA) in Rat and Human Brain Capillary Endothelial Cells(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
The ATP-binding cassette transporter subfamily A (ABCA) consists of the transporters mediating cholesterol release and regulated by cholesterol. As about 25% of total body cholesterol exists in the brain, sterol homeostasis is an important issue as far as central nervous system function is concerned. The purpose of this study was to clarify the mRNA expression of ABCA subtypes at the blood-brain barrier (BBB) using cultured rat and human brain capillary endothelial cells, TR-BBB and hBME cells, respectively. mRNA expression of ABCA1, 2, 3, 4, 5, 6, 7 and 8/9 was detected in TR-BBB cells. In the brain capillary-rich fraction, mRNA expression of ABCA1, 2, 3, 4, 5, 7 and 8/9 was detected. ABCA2 and 5 mRNA were also detected in hBME cells. These results demonstrate, for the first time, that ABCA subtypes are expressed at the rat and/or human BBB. The expression of ABCA subtypes at the BBB is likely to contribute to sterol homeostasis in the central nervous system.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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Suzuki Hiroya
Department of Internal Medicine, Tokyo Medical College Hospital
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OHTSUKI Sumio
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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HORI Satoko
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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TERASAKI Tetsuya
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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Watanabe Y
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Suzuki Hideyo
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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HORI Satoko
Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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TAKANAGA Hitomi
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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Terasaki Tetsuya
Crest Japan Science And Technology Corporation (jst)
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Terasaki Tetsuya
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Watanabe Yoshifumi
Department Of Biomolecular Engineering Tokyo Institute Of Technology
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WATANABE Yuki
Department of Computer and Mathematical Sciences, Graduate School of Information Sciences, Tohoku Un
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KAMOI Mayu
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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BHONGSATIERN Jiraganya
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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FUJIYOSHI Masachika
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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KAMIYA Naoko
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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Hori Satoko
Laboratory Of Drug Informatics Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Kamiya Naoko
Department Of Anatomy Nihon University School Of Dentistry
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Kamiya Naoko
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Ohtsuki Sumio
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Suzuki Hiroya
Department Of Internal Medicine Tokyo Medical College Hospital
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Takanaga Hitomi
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Kamoi Mayu
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Hori Satoko
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Watanabe Yuki
Department Of Computer And Mathematical Sciences Graduate School Of Information Sciences Tohoku Univ
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Bhongsatiern Jiraganya
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Fujiyoshi Masachika
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Ohtsuki Sumio
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University : New Industry Creation Hatchery Center, Tohoku University : CREST and SORST of the Japan Science and Technology Agency (JST)
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Watanabe Yoshihiko
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University
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Takanaga Hitomi
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University
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Hori Satoko
Department of Mechanical & Systems Engineering, University of Hyogo, Himeji, Hyogo 671-2280, Japan
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