Development of a Simple System for Dehydrocondensation Using Solid-Phase Adsorption of a Water-Soluble Dehydrocondensing Reagent (DMT-MM)

スポンサーリンク

概要

• 論文の詳細を見る

• It has been indicated that hydrophilic solid powder to which aqueous solution of a novel dehydrocondensing reagent DMT-MM is adsorbed becomes a simple solid-phase dehydrocondensing reagent of low cost. Reaction in a liquid-liquid biphasic system on the surface of a solid phase with a large area was accelerated by suspending this powder in a dichloromethane solution of a carboxylic acid and an amine to be condensed. The reaction was rapid with a high yield despite the heterogeneity of the system. Like general solid-phase reagents, a hydrophobic carboxamide alone could be isolated at a relatively high purity only by filtration of the resulting suspension of reaction mixture.

• 公益社団法人日本薬学会の論文
• 2004-10-01

著者

• Watanabe Y

  Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U

• Watanabe Yoshifumi

  Department Of Biomolecular Engineering Tokyo Institute Of Technology

• TANI Shohei

  Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University

• WATANABE Yasunobu

  Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University

• Tani S

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Hioki K

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University22:09:10life Science Center Kobe Gakuin Uni

• Hioki Kazuhito

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Kunishima M

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University:life Science Center Kobe Gakuin University

• Kunishima Munetaka

  Faculty Of Pharmaceutical Sciences Institute Of Medical Pharmaceutical And Health Sciences Kanazawa

• Kunishima Munetaka

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• FUJI Takako

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• Fuji T

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Watanabe Yoshihiko

  Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University

関連論文

• 5-Fluorouracil Derivatives. XXII. Synthesis and Antitumor Activities of 1-Carbamoyl-5-fluorouracils
• Effects of Methyl-β-cyclodextrin Treatment on Secretion Profile of Interferon-β and Zonula Occuludin-1 Architecture in Madin–Darby Canine Kidney Cell Monolayers
• Secretion Mode and Subcellular Localization of Human Interferon-β Exogenously Expressed in Porcine Renal Epithelial LLC-PK_1 Cells(Biopharmacy)
• Exogenous Expression of Interferon-β in Cultured Brain Microvessel Endothelial Cells(Biochemistry/Molecular Biology)
• Expression and Visualization of a Human Interferon-β-Enhanced Green Fluorescent Protein Chimeric Molecule in Cultured Cells (Biochemistry/Molecular Biology)
• Cationic Liposome-Mediated Efficient Induction of Type I Interferons by a Low Dose of Poly I:Poly C in Mouse Cell Lines
• Deformation Behaviour of Softened Celluloid under Complex Loading : Along Orthogonal Bi-linear Stress Trajectory
• Correlation of Induction of ATP Binding Cassette Transporter A5 (ABCA5) and ABCB1 mRNAs with Differentiation State of Human Colon Tumor(Molecular and Cell Biology)
• mRNA Expression of the ATP-Binding Cassette Transporter Subfamily A (ABCA) in Rat and Human Brain Capillary Endothelial Cells(Biochemistry/Molecular Biology)
• Preparation of an Artificial Cell Cycle Progressor with a Novel Mechanism
• mRNA Expression and Amino Acid Transport Characteristics of Cultured Human Brain Microvascular Endothelial Cells (hBME)
• Direct Preparation of Primary Amides by Reaction of Carboxylic Acids and Ammonia in Alcohols Using DMT-MM
• Reduction of Acetals with Samarium Diiodide in Acetonitrile in the Presence of Lewis Acids
• Coupling Reaction of Vinyl Halides with Ketones or Aldehydes Mediated by Samarium Diiodide
• [2, 3]-Wittig Rearrangement Initiated by 1, 5-Hydrogen Atom Transfer from an o-Iodophenyl Group on the α-Carbon of Allylic Ethers by Reduction with SmI_2
• REDUCTION OF DITHIOACETALS WITH SmI_2 IN BENZENE-HMPA
• A Racemization Test in Peptide Synthesis Using 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride (DMT-MM)
• Analysis of IFN-γ-Induced Cell Cycle Arrest and Cell Death in Hepatocytes^1
• Liver-Derived Matrix Metalloproteinase-9 (Gelatinase B) Recruits Progenitor Cells from Bone Marrow into the Blood Circulation
• Callosal commissural neurons of Dab1 deficient mutant mouse, yotari
• Benzyl 4,6-Dimethoxy-1,3,5-triazinyl Carbonate as N-Protecting Reagent
• Development of Novel Polymer-type Dehydro- condensing Reagents Comprised of Chlorotriazines
• Halogenolactamization of 2-(3-Butenyl)-1,3-oxazolines to Bifunctional γ-and δ-Lactams
• Immobilized Triazine-Type Dehydrocondensing Reagents for Carboxamide Formation: ROMP-Trz-Cl and ROMP(OH)-Trz-Cl
• Development of a Simple System for Dehydrocondensation Using Solid-Phase Adsorption of a Water-Soluble Dehydrocondensing Reagent (DMT-MM)
• Preparation of Weinreb Amides Using 4- (4, 6-Dimethoxy-1, 3, 5-triazin-2-yl) -4-methylmorpholinium Chloride (DMT-MM)
• Direct Evidence of Macrophage Differentiation from Bone Marrow Cells in the Liver: A Possible Origin of Kupffer Cells
• Convenient One-Pot Synthesis of 2-Oxazolines from Carboxylic Acids
• PC57 SYNTHESIS OF INOSITOL POLYPHOSPHATES
• One-Pot Preparation of Oxazol-5(4H)-ones from Amino Acids in Aqueous Solvents

もっと見る 閉じる

スポンサーリンク