A Racemization Test in Peptide Synthesis Using 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride (DMT-MM)
スポンサーリンク
概要
- 論文の詳細を見る
Racemization of the C-terminal amino acid (Ala) has been studied in various solvents during coupling between 4-methoxybenzyloxycarbonyl (Z(OMe))-GIy-L-Ala-OH and phenylalanine benzyl ester (H-Phe-OBzl) with 4-(4,6-dimethoxy-1,3,5-thiazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). The reaction occurred without substantial racemization in AcOEt, tetrahydrofuran (THF), N,N-dimethylformamide (DMF), CH_3CN, and 2-PrOH, while a slight racemization was observed in dimethyl sulfoxide (DMSO), EtOH, and MeOH. The extent of racemization may correlate with the polarity of the solvents.
- 公益社団法人日本薬学会の論文
- 2002-04-01
著者
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Watanabe Y
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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IGUCHI Shin
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Watanabe Yoshifumi
Department Of Biomolecular Engineering Tokyo Institute Of Technology
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Iguchi S
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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HIOKI Kazuhito
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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KUNISHIMA Munetaka
Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanaz
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TANI Shohei
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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KITAO Akiko
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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KAWACHI Chiho
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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WATANABE Yasunobu
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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Kitao Akiko
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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Tani S
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kawachi Chiho
Faculty Of Pharmaceutical Sciences And High Technology Research Center Kobe Gakuin University
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Hioki K
Faculty Of Pharmaceutical Sciences Kobe Gakuin University22:09:10life Science Center Kobe Gakuin Uni
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Hioki Kazuhito
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kunishima M
Faculty Of Pharmaceutical Sciences Kobe Gakuin University:life Science Center Kobe Gakuin University
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Kunishima Munetaka
Faculty Of Pharmaceutical Sciences Institute Of Medical Pharmaceutical And Health Sciences Kanazawa
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Kunishima Munetaka
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Watanabe Yoshihiko
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University
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IGUCHI Shin
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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