物理化学的視点からみた薬物の分布 (特集 物理化学的視点から医薬品をみる--化学構造・物性を臨床に活かすために)

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概要

• 論文の詳細を見る
• じほうの論文

著者

• 原島 秀吉

  北大院・薬学研究科

関連論文

• Transgene expression efficiency from plasmid DNA delivered as a complex with histone H3
• Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5
• Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues
• Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP
• UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides
• Effects of Overexpression and Antisense RNA Expression of Orf17, a MutT-Type Enzyme
• Increased A:T→C:G Mutations in the mutT Strain upon 8-Hydroxy-dGTP Treatment : Direct Evidence for MutT Involvement in the Prevention of Mutations by Oxidized dGTP
• Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine
• Roles of specialized DNA polymerases in mutagenesis by 8-hydroxyguanine in human cells
• 補体活性化に及ぼすリポソームの変動要因に関する研究 : 粒子径, コレステロールの水酸基側鎖長の影響
• Comparison between a Multifunctional Envelope-Type Nano Device and Lipoplex for Delivery to the Liver
• Stepwise dissection of the Mechanism of Macropinosomal Escape for Octaarginine Modified Nanoparticles
• オクタアルギニン修飾リポソームによるMHCクラスI特異的抗原デリバリーメカニズムの解析
• ミトコンドリアを標的としたDDSと疾患治療への応用 : ミトコンドリア融合性リポソーム、"MITO-Porter" を用いたアプローチ
• イムノリポソームの膜流動性の差が及ぼす殺細胞効果と細胞内取り込み量への影響
• PK/PDを基盤とするDDS
• 細胞内動態制御のためのインテリジェント素子の開発 : GALAとNLSによるエンドソーム膜・核膜バリアーの突破
• トランスフェリン修飾リポソームを用いたP-gpによる抗癌剤排出回避の試み
• 人工ベクターによる導入遺伝子の核内移行及び発現メカニズム(2)
• 人工ベクターによる導入遺伝子の核内移行及び発現メカニズム(1)
• 血中滞留性リポソームによる抗癌剤の処方設計における最適化
• 物理化学的視点からみた薬物の分布 (特集 物理化学的視点から医薬品をみる--化学構造・物性を臨床に活かすために)
• リポソームによる細胞内動態制御法の構築
• 人工遺伝子ベクターによる遺伝子の細胞内動態の解明 : 遺伝子の核内送達量と発現の定量的評価
• 核局在化シグナルによる遺伝子の核内送達促進は可能か?
• キャリアによる細胞内デリバリー戦略と今後の課題
• 血中滞留性リポソーム封入ドキソルビシンの腹腔癌における抗腫瘍効果制御システムの構築
• コレステロール修飾による補体回避型リポソームの開発
• リポソームによる高分子医薬品の細胞内動態制御法に関する研究(1)
• Liposome封入薬物の肝臓内動態に関する研究
• シミュレーションによるリポソーム封入ドキソルビシンの抗腫瘍効果決定因子の探索
• リポソーム膜中のコレステロール含量が及ぼす補体第3成分(C3)の結合と体内動態への影響
• In vivo 実験系による異種リポソーム間の肝取込における競合機構の解明
• 多機能性エンベロープ型ナノ構造体(MEND)を用いたタンパク質の効率的な細胞質送達
• Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue
• P-56 DNAポリメラーゼη欠損細胞抽出液によるDNA複製における8-hydroxy-dGTPの誘発変異(ポスター(2))
• MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion
• In Vitro Efficacy of a Sterically Stabilized Immunoliposomes Targeted to Membrane Type 1 Matrix Metalloproteinase (MT1-MMP)(Biopharmacy)
• Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis
• 外来DNAのトポロジー, サイズの転写効率への影響
• TAS-102経口投与におけるヒトFTD代謝の予測
• Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein
• New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX
• DNA Microarray Analysis of Whole Blood Cells and Insulin-Sensitive Tissues Reveals the Usefulness of Blood RNA Profiling as a Source of Markers for Predicting Type 2 Diabetes
• DNA Microarray Analysis of Type 2 Diabetes-Related Genes Co-regulated between White Blood Cells and Livers of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
• NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity
• Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells
• Significant and prolonged antisense effect of a multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide
• Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells
• Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract
• Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases
• Genome Wide Expression Analysis of White Blood Cells and Liver of Pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats Using a cDNA Microarray
• Cytotoxic Effect of Drosophila Deoxynucleoside Kinase Gene on Replicating Plasmid in HeLa Cells
• Induction of Various Mutations during PCRs with Manganese and 8-Hydroxy-dGTP
• PK-PD modeling of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes
• Correction of Frameshift Mutations with Single-Stranded and Double-Stranded DNA Fragments Prepared from Phagemid/Plasmid DNAs(Miscellaneous)
• RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells
• Mutagenicity of 5-Formylcytosine, an Oxidation Product of 5-Methylcytosine, in DNA in Mammalian Cells
• Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes
• Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression.
• Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcription.
• Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery
• Efficient Short Interference RNA Delivery to Tumor Cells Using a Combination of Octaarginine, GALA and Tumor-Specific, Cleavable Polyethylene Glycol System
• Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid
• A new peptide motif present in the protective antigen of anthrax toxin exerts its efficiency on the cellular uptake of liposomes and applications for a dual-ligand system
• Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria.
• Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake
• Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA
• Unexpectedly weak impacts of decreased p53 and retinoblastoma protein levels on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine)
• Cell penetrating peptide-mediated systemic siRNA delivery to the liver
• Unexpectedly Weak Impacts of Decreased p53 and Retinoblastoma Protein Levels on Mutagenesis by 8-Oxo-7, 8-dihydroguanine (8-Hydroxyguanine)
• Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery
• Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
• A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response
• Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.
• CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system
• Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect
• Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy
• Pretreatment of Hepatocyte Growth Factor Gene Transfer Mediated by Octaarginine Peptide-Modified Nanoparticles Ameliorates LPS/D-Galactosamine-Induced Hepatitis
• Vascular-targeted nanotherapy for obesity: Unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery
• A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

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