Effects of Converting Enzyme Inhibitor (SQ 20881) on Changes in Blood Pressure and Plasma Aldosterone Induced by Angiotensin I or Acute Hemorrhage in Rabbits
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概要
- 論文の詳細を見る
The effects of angiotensin converting enzyme inhibitor (CEI) upon blood pressure and plasma aldosterone (PA) were studied in rabbits with a simultaneous infusion of angiotensin I (ANG I) or with hemorrhagic hypotension.Pretreatment with CEI (SQ 20881), 1.0mg/Kg, inhibited the effects of infused ANG I, 30ng/Kg/min, upon PA and blood pressure at 30min of the infusion, but the inhibition on PA was not significant at 60min of the infusion. The same dose of CEI was ineffective in blocking the effect of 100ng/Kg/min of ANG I on PA and blood pressure even at 30min of the infusion.In rabbits with hemorrhagic hypotension, injection of CEI resulted in the decrement in blood pressure, whereas no decrement in blood pressure was observed in normal control rabbits.
- International Heart Journal刊行会の論文
著者
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Saito Ikuo
Department Of Internal Medicineicine Keio University School Of Medicine
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Saruta Takao
Department Of Clinical Pharmacology Jichi Medical School
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Kondo Kazuoki
Department Of Clinical Pharmacology Jichi Medical Schcol
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Saito Ikuo
Department Of Biotechnology Graduate School Of Engineering Nagoya University
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Eguchi Toyohisa
Department Of Internal Medicine School Of Medicine Keio University
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Misumi Jiro
Department Of Lnternal Medicine Endocrine Section Keio University School Of Medicine
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Nakamura Ryuichi
Department Of Chemical Engineering Faculty Of Engineering Tokyo Institute Of Technology
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MISUMI Jiro
Department of Internal Medicine, Keio University School of Medicine
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