Age-Related Epstein-Barr Virus-Positive Lymphoproliferative Disorders of the Orbit and Maxillary Sinus : A Case Report
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概要
- 論文の詳細を見る
We report a rare case of age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (aEBVBLPD) primarily involving the orbit and maxillary sinus. Lesions in the left orbit and maxillary sinus were observed in a 59-year-old man presenting with pain in the left orbit and maxilla. Owing to the presence of Reed-Sternberg-like cells, the initial diagnosis was nodular sclerosis-type Hodgkin's lymphoma. Clinical stage was IIAE, and response to chemotherapy and radiotherapy was favorable. Further immunohistochemical and <I>in situ</I> hybridization analyses of the Reed-Sternberg-like giant cells revealed CD30, CD15, CD20, Bob-1, Oct-2, EBV-encoded RNAs (EBERs) and latent membrane protein-1 (LMP-1) expression. The characteristics of the present case, which included immunohistochemical findings, sites of primary lesions, absence of other lymph node lesions and relatively old age, suggested aEBVBLPD. Owing to the similarity in morphology, higher frequency at extranodal sites and poor prognosis, aEBVBLPD represents a differential diagnostic issue from classical Hodgkin's lymphoma when Reed-Sternberg cells are positive for EBV. [<I>J Clin Exp Hematopathol 52(3</I><I>) </I>: <I>205-209, 2012</I>]
- 日本リンパ網内系学会の論文
著者
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MURAKAMI Hirokazu
School of Health Sciences, Faculty of Medicine, Gunma University
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Tsukamoto Norifumi
Department Of Medicine And Clinical Science
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Murakami Hirokazu
School Of Health Science Faculty Of Medicine
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Uchiumi Hideki
Department Of Applied Chemistry Nagoya Institute Of Technology
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Hirato Junko
Department Of Human Pathology Gunma University Graduate School Of Medicine
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Saitoh Takayuki
Department Of Medicine And Clinical Science Graduate School Of Medicine
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Nojima Yoshihisa
Department Of Medicine And Clinical Science Graduate School Of Medicine
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Kojima Masaru
Department Of Anatomic And Diagnostic Pathology Dokkyo Medical University
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Handa Hiroshi
Department Of Bioscience And Biotechnology Tokyo Institute Of Technology
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Mawatari Momoko
Department Of Hematology National Hospital Organization Nishigunma National Hospital
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Mitsui Takeki
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
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NAKAMURA Shigeo
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
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Yokohama Akihiko
Blood Transfusion Services Gunma University Hospital
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Karasawa Masamitsu
Department of Blood Transfusion Service, Gunma University Hospital
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Karasawa Masamitsu
Department of Internal Medicine, Usui Hospital
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Koiso Hiromi
Oncology Center
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Mawatari Momoko
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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