Molecular Detection of Cancer Cells in Saliva from Oral and Pharyngeal Cancer Patients
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概要
- 論文の詳細を見る
A key to improve the prognosis of head and neck cancers is an early diagnosis of the disease. No screening method to detect these cancers has been developed yet. Molecular techniques using polymerase chain reaction are a sensitive method to detect a small population of cancer cells among normal cells. We conducted a series of microsatellite analysis to detect cancer cells in saliva from 23 oral and pharyngeal cancer patients. Eight microsatellite markers were selected to test for microsatellite instability (MSI) in the tumor and saliva samples. Of 23 samples, 5 (22%) had MSI in the tumor samples. In 4 of 5 (80%) MSI positive samples, we detected the identical MSI in saliva. The possibility of the molecular screening and molecular follow-up is discussed.
- 東海大学の論文
著者
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TAKAHASHI Masahiro
Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefe
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Hashimoto Yoko
Department of Physiology, Yokohama City University
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Kamada Tomomi
Department Of Otolaryngology Yamaguchi University
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Hashimoto Yoko
Department Of Physiology Shimane Medical University
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OKAMI Kenji
Department of Otorhinolaryngology, Tokai University School of Medicine
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IMATE Yuji
Department of Otolaryngology School of Medicine, Yamaguchi University
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Imate Yuji
Department Of Otolaryngology Yamaguchi University
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Imate Yuji
Department Of Otolaryngology School Of Medicine Yamaguchi University
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Okami K
Tokai Univ. School Of Medicine Isehara Jpn
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Okami Kenji
Department Of Otolaryngology Tokai University School Of Medicine
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Hashimoto Yoko
Department Of Medicine And Clinical Science Graduate School Of Medicine
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Hashimoto Yoko
Department Of Otolaryngology Yamaguchi University
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Takahashi Masahiro
Department Of Advanced Pathobiology Graduate School Of Life And Environmental Sciences Osaka Prefecture University
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Takahashi Masahiro
Department Of Otolaryngology Tokai University
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