BIVENTRICULAR DOWN-REGULATION OF BETA-ADRENERGIC RECEPTORS IN RIGHT VENTRICULAR HYPERTROPHY INDUCED BY MONOCROTALINE
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the changes in beta-adrenergic receptors in the right and left ventricles during the development of cardiac hypertrophy, right ventricular hypertrophy (RVH) was induced in rats by a single injection of monocrotaline (M) (60mg/kg). The rats demonstrated RVH at 2 weeks and severe RVH with congestive heart failure at 4 weeks after the injection. Changes in the beta-adrenergic receptors in the membrane fractions of both ventricles were examined in the M-treated vs. control rats using ^<125>I-iodocyanopindolol (ICYP). Plasma and tissue catecholamines were measured. Plasma levels of nor-epinephrine (NE) and epinephrine (EP) showed no change at 2 weeks after the injection. However. at 4 weeks there was a significant increase in NE (p<0.01), but not in EP. There was no significant change in NE or EP in either ventricle at 2 weeks vs. the controls. However, at 4 weeks there was a significant increase in both NE and EP in the right ventricle (RV) (p<0.05). NE in the left ventricle (LV) tended to increase. but not a significant extent (p<0.1). With the development of RVH at 2 weeks, the maximum number of binding sites (Bmax) in both the RV and LV showed a significant decrease (p<0.01). There was a 21% decrease of Bmax in the RV and 15% in the LV at 2 weeks vs. the controls. At 4 weeks, the changes in Bmax were more prominent, with a 57% decrease in the RV and 22% in the LV. At 2 weeks the dissociation constant (Kd) of the RV decreased significantly (p<0.01), but the Kd of the LV showed no significant difference vs the control. At 4 weeks. Kd of the ventricles in the M-treated rats showed no significant difference vs. the control. These observations suggest that during the development of RVH, beta-adrenergic receptors were down-regulated not only in the hypertrophic RV but also in non-hypertrophic LV.
- 社団法人日本循環器学会の論文
- 1991-11-20
著者
-
Yamada Sachiko
The 4th Department Of Internal Medicine Shimane Medical University
-
HONDA MASAAKI
The 4th Department of Internal Medicine, Shimane Medical University
-
ISHIKAWA SHIGENORI
The 4th Department of Internal Medicine, Shimane Medical University
-
MORIOKA SHIGEFUMI
The 4th Department of Internal Medicine, Shimane Medical University
-
MORIYAMA KATSUTOSHI
The 4th Department of Internal Medicine, Shimane Medical University
-
Honda Masaaki
The 4th Department Of Internal Medicine Shimane Medical University
-
MORIOKA Shigefumi
Cardiovascular Division, Kobe General Hospital
-
Morioka Shigefumi
Fourth Department Of Internal Medicine Shimane Medical University
-
Moriyama Katsutoshi
The Fourth Department Of Internal Medicine Shimane University
-
Moriyama Katsutoshi
The 4th Department Of Internal Medicine Shimane Medical University
-
Ishikawa Shigenori
The 4th Department Of Internal Medicine Shimane Medical University
-
Morioka Shigefumi
The 4th Department Of Internal Medicine Shimane Medical University
関連論文
- BIOCHEMICAL REMODELING OF COLLAGEN IN THE HEART OF SPONTANEOUSLY HYPERTENSIVE RATS : Prominent Increase in Type V Collagen
- EFFECTS OF E-1020, A NEW CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITOR, ON CYCLIC AMP AND CYTOSOLIC FREE CALCIUIM OF CULTURED VASCULAR SMOOTH MUSCLE CELLS : The 53th Annual Scientific Session of the Japanese Circulation Society
- STUDY OF THE PATHOGENESIS OF CARDIAC HYPERTROPHY : Biochemical Differences of Cultured Heart Cells from Normotensive and Spontaneously Hypertensive Rats
- EFFECTS OF E-1020, A NEW cAMP-SPECIFIC PHOSPHODIESTERASE INHIBITOR, ON PROTEIN METABOLISM OF HEART AND cAMP OR CYTOSOLIC FREE Ca^ OF VASCULAR SMOOTH MUSCLE CELLS : Cardiovascular Drugs : 53 Annual Scientific Meeting, Japanese Circulation Society
- -P210- THE METABOLIC DIFFERENCES OF CULTURED HEART CELLS IN SHR & WKY
- THE EFFECTS OF CORONARY REPERFUSION ON SARCOLEMMAL Na^+, K^+-ATPase ACTIVITY IN DOGS
- A Probable Relationship between an Endogenous Digitalis-Like Substance and Concentric Cardiac Hypertrophy in Primary Aldosteronism
- VECTORCARDIOGRAPHIC (VCG) PATTERNS OF HYPERTROPHIC CARDIOMYOPATHY (HCM) - A COMPARABLE STUDY WITH ANATOMICAL TYPES : Vectorcardiography, Electrophysiology : IVth Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Toky
- Extensive myocardial abscess complicated by myocardial infarction
- REGULATION OF EXTERNAL WORK OF CONCENTRIC HYPERTROPHIED LEFT VENTRICLES IN UNANESTHETIZED HYPERTENSIVE DOGS
- STUDY OF CARDIAC HYPERTROPHY : Humoral Factors that Stimulate Protein Metabolism of Cultured Rat Heart Cells
- -356-THE SIGNIFICANCE OF LEFTWARD PARALLEL SHIFT OF THE END-SYSTOLIC WALL STRESS-DIMENSION RELATION FOR INOTROPIC STATE OF THE HYPERTROPHIED LEFT VENTRICLE IN UNANESTHETIZED HYPERTENSIVE DOGS : Ventricular Function : FREE COMMUNICATIONS(II) : PROCEEDINGS
- LEFT VENTRICULAR END-SYSTOLIC WALL STRESS-DIMENSION RELATIONSHIP IN UNANESTHETIZED DOGS WITH PERINEPHRITIC HYPERTENSION
- -P209- STUDY OF HUMORAL FACTOR (S) FOR CARDIAC HYPERTROPHY IN EXPERIMENTAL RENAL HYPERTENSION
- -135-STUDY ON LOAD DEPENDENCY OF MAX dp/dt-ENDDIASTOLIC SEGMENT LENGTH RELATION IN DOGS
- MARKED PULMONARY HYPERTENSION ASSOCIATED WITH INTERSTITIAL PNEUMONITIS INDUCED BY GOLD THERAPY
- THE COMPARISION OF INFARCT HEART ADAPTABILITY TO ANY GIVEN VOLUME AND/OR PRESSURE OVERLOADING IN NIFEDIPINE AND TRAPIDIL-TREATED DOOS, NIFEDIPINE-TREATED DOGS AND NON-TREATED DOGS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULA
- THE DEVELOPMENT AND FUNCTION OF HYPERTROPHIED HEART IN RENAL HYPERTENSIVE DOGS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Pathophysiology
- THE STUDY OF NON-INVASIVE ASSESSMENT OF PULMONARY HYPERTENSION : Pulmonary Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- BIOCHEMICAL AND STRUCTURAL REMODELING OF COLLAGEN IN THE RIGHT VENTRICULAR HYPERTROPHY INDUCED BY MONOCROTALINE
- BIVENTRICULAR DOWN-REGULATION OF BETA-ADRENERGIC RECEPTORS IN RIGHT VENTRICULAR HYPERTROPHY INDUCED BY MONOCROTALINE
- -0241-BIVENTRICULAR DOWN-REGULATIONS OF BETA-ADRENERGIC RECEPTOR IN THE HEART TREATED WITH MONOCROTALINE
- -0240-COLLAGEN REMODELING OF RIGHT VENTRICLE IN RESPONSE TO PRESSURE OVERLOAD
- Effects of Balloon Pulmonary Valvuloplasty on Atrial Shunting : A Patient With Pulmonary Valve Stenosis and A Large Secundum Atrial Septal Defect
- Clinical Implications of Echocardiographic Findings and Atrial Natriuretic Peptide Level Before and After Hemodialysis in Patients With Chronic Renal Failure
- Prediction of Outcome of Electrical Cardioversion by Left Atrial Appendage Flow Velocities in Atrial Fibrillation
- Effect of home oxygen therapy (HOT) on the prognosis in chronic hypoxemic pulmonary disease
- EVALUATING CORONARY REPERFUSION DURING ACUTE MYOCARDIAL INFARCTION IN A CANINE MODEL BY GADOLINIUTPA-ENHANCED MAGNETIC RESONANCE IMAGING
- Anti-apoptotic effect of atorvastatin, a HMG-CoA reductase inhibitor, on cardiac myocyte via PKC activation
- Negative Contraction-Frequency Relation Is Mediated by Dysfunction of CaMKII in Failing Rat Cardiomyocytes
- A Calcium Antagonist Protects against Doxorubicin-Induced Impairment of Calcium Handling in Neonatal Rat Cardiac Myocytes
- Doxorubicin Cardiotoxicity : Diastolic Cardiac Myocyte Dysfunction as a Result of Impaired Calcium Handling in Isolated Cardiac Myocytes
- Effects of an AEC Inhibitor, enaiapril, and a β blocker, atenolol, on Collagen During Development and Inhibition of Cardiac Hypertrophy in Bio 14.6 Hamsters
- -1001-RIGHT HEART FILLING DYNAMICS IN PATIENTS WITH DILATED CARDIOMYOPATHY HAVING ATRIAL FIBRILLATION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- ISOVOLUMIC RELAXATION PERIOD AS AN INDEX OF LEFT VENTRICULAR RELAXATION UNDER DIFFERENT AFTERLOAD CONDITIONS : Comparison with the Time Constant of Left Ventricular Pressure Decay in the Dog
- CARDIAC EFFECTS OF PROPRANOLOL AND TIMOLOL IN HYPERTENSION : ASSESSMENT BY FOUR NONINVASIVE METHODS AT REST AND DURING EXERCISE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardiovascular Drugs (I)
- COLLAGEN IN DILATED CARDIOMYOPATHY : Scanning Electron Microscopic and Immunohistochemical Observations
- Changes in Contractile and Non-Contractile Proteins, Intracellular Ca^ and Ultrastructures During The Development of Right Ventricular Hypertrophy and Failure in Rats : COMPENSATORY MECHANISMS AND THEIR LIMITATIONS IN HEART FAILURE
- -1045-COLLAGEN REMODELING IN THE HUMAN HYPERTENSIVE HYPERTROPHIED HEARTS : IMMUNOHISTOCHEMICAL AND SCANNING ELECTRON MICRASCOPIC OBSERVATIONS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0073-REMODELING OF COLLAGENS IN HUMAN HYPERTENSIVE HYPERTROPHIED HEARTS : COLLAGEN CONTENTS, PROPORTION AND DISTRIBUTION OF TYPE I, III, V COLLAGEN
- -0032-MORPHOLOGICAL CHARACTERISTICS OF COLLAGENS IN DILATED CARDIOMYOPATHY : SCANNING ELECTRON MICROSCOPIC AND IMMUNOHISTOCHEMICAL OBSERVATIONS
- FIELD EMISSION SCANNING ELECTRON MICROSCOPIC STUDY ON THE NONINFARCTED MYOCARDIUM AFTER MYOCARDIAL INFARCTION : The 53th Annual Scientific Session of the Japanese Circulation Society
- Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline
- IMPROVEMENT OF RIGHT VENTRICULAR SYSTOLIC PERFORMANCE BY LONG-TERM DOMICILIARY OXYGEN THERAPY IN PATIENTS WITH CHRONIC RESPIRATORY FAILURE
- ALTERATION OF LEFT VENTRICULAR GEOMETRY DURING PRELOAD REDUCTION AND AFTERLOAD INCREMENT
- -461- ACUTE AND CHRONIC EFFECTS OF ICI 118,587 (CORWIN) IN PATIENTS WITH CHRONIC HEART FAILURE
- Phasic Venous Return Abnormality in Chronic Pulmonary Diseases: Pulsed Doppler Echocardiography Study.
- Utilization of Salivary Level Monitoring of Mexiletine in the Therapy of Arrhythmic Patients.