LEFT VENTRICULAR END-SYSTOLIC WALL STRESS-DIMENSION RELATIONSHIP IN UNANESTHETIZED DOGS WITH PERINEPHRITIC HYPERTENSION

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To study myocardial contractility in hypertensive hearts with normal wall motion, we examined left ventricular end-systolic wall stress-dimension relationships (ESWDR) during a baseline period (CS: control stage) and in the eighth week after induction of systemic hypertension by Page's method (HS: hypertensive stage) in unanesthetized dogs. The mean aortic blood pressure increased from 94 ± 11 to 142 ± 26 mmHg (p<0.01). The end-diastolic left ventricular posterior wall thickness increased significantly during the HS (9.4 ± 1.3 vs 7.3 ± 1.3 mm; HS vs CS), and its dimension was significantly (p<0.05) smaller than it was during the CS (37.0 ± 4.2 vs 39.9 ± 4.6 mm; HS vs CS). There were no significant differences between the 2 stages in left ventricular fractional shortening (31.9 ±5.0 vs 32.6 ± 2.8; HS vs CS), in end-systolic meridional left ventricular wall stress (75.3 ± 10.8 vs 68.3 ± 15.6 10^3 dynes/cm^2; HS vs CS), or in he ESWDR slopes (98.6 ± 17.7 vs 94.0 ±19.7; HS vs CS). The ESWDR dimension intercepts significantly decreased from 2.0 0.3 to 1.8 0.3 cm during the HS; that is, the relationship shifted to the left with no significant change in the slope. At autopsy, the ratio of left with no significant change in the slope. At autopsy, the ratio of left ventricular weight to body weight of the hypertensive dogs was significantly (p<0.01) grater than that of sham-operated control dogs (6.0 0.9 vs 4.3 0.5 g/kg). These findings indicated that myocardial contractility was normal in concentric hypertrophied hearts induced by systemic hypertension, although the cause of the decreased ESWDR dimension intercept remains unknown.
社団法人日本循環器学会の論文
1988-12-20

LEFT VENTRICULAR END-SYSTOLIC WALL STRESS-DIMENSION RELATIONSHIP IN UNANESTHETIZED DOGS WITH PERINEPHRITIC HYPERTENSION

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