FIELD EMISSION SCANNING ELECTRON MICROSCOPIC STUDY ON THE NONINFARCTED MYOCARDIUM AFTER MYOCARDIAL INFARCTION : The 53th Annual Scientific Session of the Japanese Circulation Society

概要

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Intracellular membranous ultrastructural changes in the noninfarcted myocardium of the left ventricle were studied by examining experimental myocardial infarction in rats with a field emission scanning electron microscope. The left coronary artery was ligated at its origin for 7 days. The resulting infarcts comprised approximately 40% of the total area of the left ventricles. In a light microscopic study, the transverse diameter of myocytes had increased to 17.1±2.9μm in the noninfarcted myocardium, compared to 14.1±3 .1 μm in the myocardium of sham-operated rats (p<0.01). For the scanning electron microscopic study, the specimens were processed according to the Osmium-DMSp-Osmium method. Marked morphological changes of intracellular membranous structures were found in the noninfarcted myocardium, especially in the lacelike network of sarcoplamic reticulum which occasionally formed large flattened cisternae, and in the marked proliferation of surface caveolae. It is speculated that these early ultrastructural changes in the noninfarcted myocardium reflect an adaptation of microorganellae in the failing hearts of the rats.
社団法人日本循環器学会の論文
1990-06-20