Anemia as a Factor That Elevates Plasma Brain Natriuretic Peptide Concentration in Apparently Healthy Subjects
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概要
- 論文の詳細を見る
Plasma brain natriuretic peptide (BNP) is widely used as a biomarker of heart failure (HF); however, its concentration is often found to be high even in apparently healthy subjects and little is known about which factors contribute to physiological change in plasma BNP concentration in subjects without HF. We examined the effects of gender, age, and anemia on plasma BNP concentration in apparently healthy subjects. The study population consisted of 1036 healthy subjects who underwent an annual health examination at their company in 2005. There were 874 women, ranging in age from 30 to 63 years (mean, 41 years). Plasma BNP concentration was abnormal (> 18.4 pg/mL) in 292 subjects. The incidence was significantly higher in women than in men (31% versus 14%, P < 0.01). Mean plasma BNP concentration was higher in women than in men. The difference in plasma BNP concentration was associated with the difference in blood hemoglobin and age. Logarithmically transformed BNP concentration correlated inversely with blood hemoglobin (r = -0.30, P < 0.01 for all; r = -0.21, P < 0.01 for women; r = -0.20, P < 0.01 for men). By multiple regression analysis, logarithmically transformed BNP concentration correlated with hemoglobin, age, and gender. In conclusion, anemia is likely a critical determinant that elevates plasma BNP concentration in apparently healthy subjects.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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MATSUMOTO Mika
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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TSUJINO Takeshi
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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LEE-KAWABATA Masaaki
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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NAITO Yoshiro
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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MASUYAMA Tohru
Cardiovascular Division, Department of Internal Medicine Hyogo College of Medicine
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Mano Toshiaki
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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Yamamoto Kazuhiro
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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Mano Toshiaki
大阪大学大学院医学系研究科・臨床医工学融合研究教育センター
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Mano Toshiaki
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Masuyama Tohru
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Tsujino Takeshi
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Tsujino Takeshi
兵庫医科大学 循環器内科
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Ezumi Akira
Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine
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Ezumi Akira
Cardiovascular Division Osaka Railway Hospital Of West Japan Railway Company
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Matsumoto Mika
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Naito Yoshiro
Cardiovascular Division Department Of Internal Medicine Hyogo College Of Medicine
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Yamamoto Kazuhiro
Department of Biochemistry, Kinki University
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Lee-Kawabata Masaaki
Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine
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