Role of Activated Renin-Angiotensin System in Myocardial Fibrosis and Left Ventricular Diastolic Dysfunction in Diabetic Patients : Reversal by Chronic Angiotensin II Type 1A Receptor Blockade

概要

論文の詳細を見る
Background We attempted to test the hypothesis that chronic angiotensin n type 1A receptor blockade (ARE) alters myocardial collagen turnover leading to an improvement of diastolic dysfunction in diabetic patients. Methods and Results Forty-eight type 2 diabetic patients were divided into 2 groups: 38 treated with candesartan for 6 months, and 10 without candesartan, as controls. Doppler mitral flow velocity pattern and biomarkers of collagen type I turnover were assessed before and after ARB during a 6-month period. The mitral E/A ratioincreased from 0.65±0.11 to 0.75±0.19. The carboxy-terminal propeptide of procollagen type I (PIP), an index ofcollagen type I synthesis, decreased and the carboxy-terminal telopeptide of collagen type I (CITP), an index ofcollagen type I degradation, increased following ARB. Consequently, the PIP/CITP ratio, an index of couplingbetween the synthesis and degradation of collagen type I, decreased. None of the indexes changed in the control group. The change in left ventricular chamber stiffness did not correlate with the change in PICP (r=0.08, p=NS), but it did with the changes in CITP or in the PIP/CITP ratio (r=0.35, p<0.05; r=0.39, p<0.05). Conclusions Chronic ARB improves diastolic dysfunction in diabetic patients, at least partially through the attenuation of myocardial fibrosis, by regulating collagen turnover, particularly by facilitating collagen degradation.
社団法人日本循環器学会の論文
2007-03-20

Role of Activated Renin-Angiotensin System in Myocardial Fibrosis and Left Ventricular Diastolic Dysfunction in Diabetic Patients : Reversal by Chronic Angiotensin II Type 1A Receptor Blockade

スポンサーリンク

概要

著者

関連論文

スポンサーリンク