Preventive Effects of the Plant Isoflavones, Daidzin and Genistin, on Bone Loss in Ovariectomized Rats Fed a Calcium-Deficient Diet

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概要

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• The effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized (ovx) rats fed a calcium-deficient diet were investigated. Daidzin and genistin were orally administered to ovx rats for 4 weeks. The femurs of these rats showed significantly lower density, strength (breaking forces), ash weight and calcium and phosphorus content (p<0.01) in comparison with those of sham-operated rats. These changes were largely prevented in animals receiving oral daidzin or genistin for 4 weeks at a dose of 50mg/kg/d and in animals receiving subcutaneous estrone (7.5μg/kg/d) as a positive control. Ovariectomy caused atrophy of the uterus and increased the ratio of the urinary excretion of pyridinoline and deoxypyridinoline to endogenous creatinine excretion. This was prevented by administration of daidzin or estrone, but, interestingly, not genistin. The preventive effect of daidzin treatment on bone loss in ovariectomized rats appears to be due to suppression of bone turnover.Genistin has a different mechanism of action from daidzin.

• 公益社団法人日本薬学会の論文
• 1998-01-15

著者

• 辻 浩一

  Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.

• TODA Toshiya

  Fujicco Co., Ltd.

• Ishida H

  School Of Pharmaceutical Science University Of Shizuoka

• Tsuji Kiyoshi

  Medicinal Chemistry Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hirai Kuniaki

  Products Safety & Akohol Science Laboratory Suntory Limited

• Yokotsuka Koki

  The Institute Of Enology And Viticulture Yamanashi University

• Nukaya Haruo

  School of Pharmaceutical Sciences, University of Shizuoka

• ISHIDA HITOSHI

  School of Pharmaceutical Science, University of Shizuoka

• TSUJI KUNIRO

  School of Pharmaceutical Science, University of Shizuoka

• UESUGI Takehiko

  Fujicco Ltd.

• HIRAI Kuniaki

  Fujicco Co., Ltd.,

• Hirai K

  Sankyo Co. Ltd. Kanagawa Jpn

• Tsuji K

  School Of Pharmaceutical Science University Of Shizuoka

• 辻 京子

  Faculty Of Pharmaceutical Sciences Setsunan University

• Nukaya H

  School Of Pharmaceutical Science University Of Shizuoka

• Toda T

  Konan Univ. Kobe Jpn

• Toda Toshiya

  Fujicco Co. Ltd.

• Nukaya Haruo

  School Of Pharmaceutical Science University Of Shizuoka

• Toda Tatsushi

  Division Of Functional Genomics Department Of Post-genomics And Diseases Osaka University Graduate S

• Ishida Hitoshi

  Research Institute For Bioresources Okayama University:(present Office)plant Protection Station Moji

• Yokotsuka Koki

  The Institute Of Enology And Viticulture

• Uesugi T

  Fujicco Co. Ltd. Kobe Jpn

• Uesugi Takehiko

  Research & Development Laboratory Fujicco Co. Ltd.

• Yokotsuka Koki

  The Institute Of Ecology And Viticulture Yamanashi University

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