Effect of Dietary Fiber in Edible Seaweeds on the Development of D-Galactosamine-Induced Hepatopathy in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Previous studies in our laboratory demonstrated the repressive effect of seaweeds (Laminaria sp., Sargassum fulvellum, Eisenia bicyclis and Gelidium sp.) against D-galactosamine (D-GalN)-induced hepatopathy. However, the mechanism by which these four seaweeds attenuate the D-GalN-hepatopathy has not been completely clarified. This study was carried out to determine the constituents of these seaweeds that protect rats against the D-GalN-hepatopathy. Male Wistar rats were fed for 8d diets containing 5% seaweeds with or without the antibiotic neomycin (NEO) in experiment 1, and typical seaweed dietary fibers (laminaran, fucoidan, alginate, agar and κ-carrageenan) of these seaweeds in experiment 2. On the 7th day, the rats were treated with D-GalN (1,900mg in experiment 1 and 800mg/kg in experiment 2) and then sacrificed 24h after the injection of D-GalN. Their serum transaminase (aspartate and alanine aminotransferases : AST and ALT) activities were then determined. In experiment 1, the serum AST and ALT levels in the rats fed the four kinds of seaweeds without NEO were significantly low in comparison to that of the control group, but those with NEO were not significantly different among the groups. In experiment 2, the serum AST and ALT levels in the rats fed fucoidan were significantly low in comparison to those of the other groups fed the dietary fibers and the control. These results suggest that the protective effect of the three kinds of brown seaweeds Laminaria sp., Sargassum fulvellum and Eisenia bicyclis against D-GalN-hepatopathy was caused at least in part by fucoidan.
- 日本ビタミン学会の論文
著者
-
Sanada Hiroo
Laboratory of Foods and Nutritional Chemistry, Department of Agricultural Chemistry, Faculty of Hort
-
Sanada Hiroo
Laboratory Of Food And Nutrition Graduate School Of Science And Technology Chiba University
-
Kawano Naoko
Laboratory Of Food And Nutrition Graduate School Of Science And Technology Chiba University:departme
-
Egashira Yukari
Laboratory Of Food And Nutrition Graduate School Of Science And Technology Chiba University
-
Sanada Hiroo
Graduate School Of Sci. And Technol. Chiba Univ.
-
Egashira Yukari
Graduate School Of Sci. And Technol. Chiba Univ.
-
Sanada Hiroo
Laboratory Of Food And Nutrition Graduate School Of Horticulture Chiba University
-
Egashira Yukari
Laboratory Of Food And Nutrition Graduate School Of Horticulture Chiba University
関連論文
- Components of the Gel of Aloe vera (L.) Burm. f.
- Ginkgo biloba Extract markedly Induces Pentoxyresorufin O-Dealkylase Activity in Rats
- Effects of Various Kinds of Dietary Amino Acids on the Hepatotoxic Action of D-Galactosamine in Rats
- Effect of Indigestible Oligosaccharides on the Hepatotoxic Action of D-Galactosamine in Rats
- Effect of Dietary Fiber in Edible Seaweeds on the Development of D-Galactosamine-Induced Hepatopathy in Rats
- Effects of Various Kinds of Edible Seaweeds in Diets on the Development of D-Galactosamine-Induced Hepatopathy in Rats
- Effects of Dietary Corn Bran Hemicellulose and Neomycin on Hepatic Caspase-3 Activity and Glycoprotein Concentration in Rats Treated with or without D-Galactosamine
- Histopathological and Immunological Analysis of the Effects of Butylated Antioxidants on Acetaminophen - Hepatotoxity in Rats
- Restraint of Acetaminophen - Induced Liver Injury with Butylated Hydroxyanisole and Butylated Hydroxytoluene, and Its Effects on Hepatic Heat Shock Protein 25 and 70i
- Release of Ferulic Acid from Wheat Bran by an Inducible Feruloyl Esterase from an Intestinal Bacterium Lactobacillus acidophilus
- Hypocholesterolemic Mechanism of Chlorella : Chlorella and Its Indigestible Fraction Enhance Hepatic Cholesterol Catabolism through Up-Regulation of Cholesterol 7α-Hydroxylase in Rats
- Differences between the Antioxidation Effects of Butylated Hydroxyanisole and Butylated Hydroxytoluene on Acetaminophen - Induced Hepatic Metabolism in Rats
- Protective Effect of Butylated Hydroxyanisole and Butylated Hydroxytoluene against Acetaminophen-Induced Hepatotoxicity in Rats
- Protective Effect of Red-Stemmed Type of Ipomoea aquatica Forsk against CCl4-Induced Oxidative Damage in Mice
- Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats
- Effect of Dietary Phytol on the Expression of α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase, a Key Enzyme of Tryptophan-niacin Metabolism, in Rats