Dietary Linoleic Acid Alters α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD), a Key Enzyme of Niacin Synthesis from Tryptophan, in the Process of Protein Expression in Rat Liver
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概要
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α-Amino-β-carboxymuconate-8-semialdehyde decarboxylase (ACMSD) [EC 4.1.1.45] is a key enzyme of niacin synthesis from tryptophan. In this study, we examined whether dietary linoleic acid alters the protein expression of ACMSD in rat liver. Antibody against rat liver ACMSD was prepared by injecting mice with the purified enzyme. With the use of this polyclonal antibody and analysis by two-dimensional electrophoresis, we studied the mechanism by which the level of liver ACMSD activity was varied in rats fed a linoleic acid diet. In the rats fed a dietary linoleic acid (L), ACMSD protein levels in the liver were strongly suppressed as compared with the rats fed a fat-free diet (FF). These results suggest that the expression level of ACMSD might be modulated by linoleic acid or their metabolites.
- 財団法人 学会誌刊行センターの論文
著者
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Sanada Hiroo
Department Of Agricultural Chemistry Faculty Of Horticulature Chiba University
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OHTA Takeo
Department of Bioproduction Science, Faculty of Horticulture, Chiba University
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Egashira Y
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Egashira Yukari
Department Of Bioproduction Science Faculty Of Horticulture Chiba University
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Tanabe Atsushi
Department Of Gastroenterology Ehime Prefectural Central Hospital
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SANADA Hiroo
Department of Bioproduction Science, Faculty of Horticulture
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OHTA Takeo
Department of Bioproduction Science, Faculty of Horticulture
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EGASHIRA Yukari
Department of Bioproduction Science, Faculty of Horticulture
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TANABE Atsushi
Department of Bioproduction Science, Faculty of Horticulture
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OHTA Takeo
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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