Protein-losing Enteropathy Associated with Collagenous Colitis Cured by Withdrawal of a Proton Pump Inhibitor
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概要
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A 63-year-old woman was admitted with symptoms of watery diarrhea and generalized edema lasting for five months. She had been administered 15 mg/day of lansoprazole. Laboratory findings revealed severe hypoproteinemia with normal liver, renal, thyroid and adrenal functions and no proteinuria. Colonoscopy revealed edematous mucosa, minor diminished vascular transparency and apparent longitudinal linear lacerations. The histopathological findings were compatible with a diagnosis of collagenous colitis (CC). Protein leakage from the colon was identified on 99mTc-human serum albumin scintigraphy. The results indicated CC associated with protein-losing enteropathy. Discontinuing lansoprazole ameliorated the watery diarrhea and generalized edema, increased the serum albumin level and improved the hypoproteinemia.
著者
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Kasugai Kunio
Department Of Gastroenterology Aichi Medical University Hospital
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Ogasawara Naotaka
Department Of Gastroenterology Aichi Medical University School Of Medicine
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Mizuno Mari
Department Of Gastroenterology Aichi Medical University School Of Medicine
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Sasaki Makoto
Deparment Of Mathematical System Science Faculty Of Science And Technology Hirosaki University
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TANABE Atsushi
Department of Bioproduction Science, Faculty of Horticulture
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Ogasawara Naotaka
Department of Gastroenterology, Aichi Medical University School of Medicine, Japan
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Ozeki Tomonori
Department of Gastroenterology, Aichi Medical University School of Medicine, Japan
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Izawa Shinya
Department of Gastroenterology, Aichi Medical University School of Medicine, Japan
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Yanamoto Kenichiro
Department of Gastroenterology, Aichi Medical University School of Medicine, Japan
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Noda Hisatsugu
Department of Gastroenterology, Aichi Medical University School of Medicine, Japan
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Okaniwa Noriko
Department of Gastroenterology, Aichi Medical University School of Medicine, Japan
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Mizuno Mari
Department of Gastroenterology, Aichi Medical University School of Medicine, Japan
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