Synthesis of skeleton of antitumor quassinoid.

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概要

• 論文の詳細を見る

• A compound having a skeleton of an antitumor quassinoid, bruceantin, was prepared according to the following strategy; 1) construction of ring ABC from ring AB by cyclization of a hindered 1,5-diketone; 2) construction of ring E (ether ring) by opening of a 12,13-epoxide ring followed by attack of oxygen at C-20 toward C-13; 3) formation of ring D (hemiacetal ring) by treatment of a 7α-hydroxy-16-al dimethyl acetal with PPTS.

• 公益社団法人 日本化学会の論文

著者

• Murae Tatsushi

  Department Of Chemistry Faculty Of Science The University Of Tokyo

• Matsuo Hisaaki

  Department Of Chemistry Faculty Of Science The University Of Tokyo

• Usuki Yoshinosuke

  Department Of Chemistry College Of Arts And Sciences The University Of Tokyo

• Takahashi Takeyoshi

  Department Of Applied Biological Science College Of Agriculture And Veterinary Medicine Nihon Univer

• Konosu Toshiyuki

  Department Of Chemistry Faculty Of Science The University Of Tokyo

• Sasaki Makoto

  Deparment Of Mathematical System Science Faculty Of Science And Technology Hirosaki University

• TANAKA Naoko

  Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• SASAKI Makoto

  Department of Chemistry, Faculty of Science, The University of Tokyo

• Usuki Yoshinosuke

  Department of Chemistry, Faculty of Science, The University of Tokyo

• Yagi Kiyoshi

  Department of Chemistry, Faculty of Science, The University of Tokyo

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