Synthesis of skeleton of antitumor quassinoid.
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概要
- 論文の詳細を見る
A compound having a skeleton of an antitumor quassinoid, bruceantin, was prepared according to the following strategy; 1) construction of ring ABC from ring AB by cyclization of a hindered 1,5-diketone; 2) construction of ring E (ether ring) by opening of a 12,13-epoxide ring followed by attack of oxygen at C-20 toward C-13; 3) formation of ring D (hemiacetal ring) by treatment of a 7α-hydroxy-16-al dimethyl acetal with PPTS.
- 公益社団法人 日本化学会の論文
著者
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Murae Tatsushi
Department Of Chemistry Faculty Of Science The University Of Tokyo
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Matsuo Hisaaki
Department Of Chemistry Faculty Of Science The University Of Tokyo
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Usuki Yoshinosuke
Department Of Chemistry College Of Arts And Sciences The University Of Tokyo
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Takahashi Takeyoshi
Department Of Applied Biological Science College Of Agriculture And Veterinary Medicine Nihon Univer
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Konosu Toshiyuki
Department Of Chemistry Faculty Of Science The University Of Tokyo
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Sasaki Makoto
Deparment Of Mathematical System Science Faculty Of Science And Technology Hirosaki University
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TANAKA Naoko
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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SASAKI Makoto
Department of Chemistry, Faculty of Science, The University of Tokyo
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Usuki Yoshinosuke
Department of Chemistry, Faculty of Science, The University of Tokyo
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Yagi Kiyoshi
Department of Chemistry, Faculty of Science, The University of Tokyo
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