Triple Therapy with Ecabet Sodium, Amoxicillin and Lansoprazole for 2 Weeks as the Rescue Regimen for H. pylori Infection
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概要
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Background/Aim Ecabet sodium has an anti-H. pylori effect. We assessed the efficacy of ecabet sodium in the rescue therapy for the eradication of H. pylori. Methods A total of 74 patients with failed eradication of H. pylori after triple therapy with lansoprazole 30 mg bid, amoxicillin 750 mg bid and clarithromycin 200 mg bid were enrolled. They were randomly assigned to the three treatment groups as follows: LAC, lansoprazole 30 mg + amoxicillin 750 mg + clarithromycin 200 mg bid for 1 week; LAC2E, lansoprazole 30 mg bid + amoxicillin 750 mg bid + clarithromycin 200 mg bid + ecabet sodium 2 g bid for 1 week; and LA2E, lansoprazole 30 mg bid + amoxicillin 750 mg bid + ecabet sodium 2 g bid for 2 weeks. Eradication of H. pylori was assessed by the 13C-urea breath test after treatment. Results Eradication rates in intention-to-treat and per-protocol analyses were 20.0% (95% CI: 6.8-40.7) and 20.0% (6.8-40.7) with LAC, respectively, and 16.0% (4.5-36.1) and 17.4% (5.0-38.8) with LAC2E. In contrast, respective rates with LA2E were 75% (53.3-90.2) and 85.7% (63.7-97.0), which were significantly higher than those with LAC (p<0.001 for both ITT and PP) and LAC2E (p<0.001 for both ITT and PP). Conclusion Triple therapy with ecabet sodium, lansoprazole and amoxicillin for 2 weeks was effective as the rescue therapy after failure of the standard clarithromycin-based regimen.
著者
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Nomura Hideyuki
The Center For Liver Diseases Shin-kokura Hospital
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Kato Mototsugu
Division Of Endoscopy Hokkaido University Hospital
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Shirai Takayuki
Department Of Internal Medicine (gastroenterology) Tokai University School Of Medicine
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Furuta Takahisa
Center For Clinical Research Hamamatsu University School Of Medicine
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Kamoshida Toshiro
Department Of Internal Medicine Hitachi General Hospital
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Ishii Naoki
Department Of Gastroenterology St Luke's International Hospital
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Sasaki Makoto
Deparment Of Mathematical System Science Faculty Of Science And Technology Hirosaki University
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Asaka Masahiro
Department Of Cancer Preventive Medicine Graduate School Of Medicine Hokkaido University
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Konda Yoshitaka
Department of Gastroenterogy and Hepatology, Graduate School of Medicine, Kyoto University, Japan
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Sasaki Makoto
Department of Gastroenterology, Aichi Medical University School of Medicine, Japan
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Sugimoto Mitsushige
Center for Clinical Research, Hamamatsu University School of Medicine, Japan
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Furukawa Kouichi
Department of Gastroenterology, Niigata City General Hospital, Japan
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Inaba Tomoki
Department of Gastroenterology, Kagawa Prefectural Central Hospital, Japan
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Tomita Takashige
Department of Gastroenterology, Toshiba General Hospital, Japan
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Konda Yoshitaka
Department of Gastroenterology, Higashiyama Takeda Hospital, Japan
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Ishii Naoki
Department of Gastroenterology (Gastroenterology Center), St. Luke's International Hospital, Japan
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Kato Mototsugu
Division of Endoscopy, Hokkaido University Hospital, Japan
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Asaka Masahiro
Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Japan
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