Effects of Dietary Gluten on the Hepatotoxic Action of Galactosamine and/or Endotoxin in Rats

概要

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This study was done to clarify the effects of dietary wheat gluten on the hepatotoxic action of D-galactosamine (GalN) and endotoxin (Etx). Male Wistar rats fed a high casein or high gluten (supplemented with L-Lys and L-Thr) diet were injected with GalN or Etx, and the plasma glutamate oxaloacetate transaminiase, glutamate pyruvate transaminase, and lactase dehydrogenase activities were examined 20h later. In rats fed the high gluten diet, these enzyme activities were lower than in the high casein group after injection of 800mg/kg of GalN. But such a difference between the casein and gluten groups was not clear when they were treated with 400 mg/kg of GalN nor observed even after injection of Etx or Etx + GalN (400mg/kg). Similarly these was no difference in the plasma concentrations of Etx, tumor necrosis factor-alpha, or interferon-gamma in the rats receiving an injection of 800mg/kg of GalN between both dietary groups. These results suggest that dietary gluten affords protection against hepatic injury by a high dose of GalN but not by a low dose of GalN and/or Etx.
社団法人日本農芸化学会の論文
1996-03-23