Effects of Excess Biotin Administration on the Growth and Urinary Excretion of Water-Soluble Vitamins in Young Rats
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概要
- 論文の詳細を見る
To determine the effects of excess biotin administration on growth and water-soluble vitamin metabolism, weaning rats were fed on a 20% casein diet containing 0.00002% biotin, or same diet with 0.04, 0.08, 0.10, 0.20, 0.50, 0.80 or 1.0% added biotin for 28 days. More than 0.08% biotin administration decreased the food intake and body weight gain compared with the levels in control rats. An accumulation of biotin in such tissues as the liver, brain and kidney increased in a dose-dependent manner, and the both bound and free biotin contents in the liver also increased in a dose-dependent manner. An excess administration of biotin did not affect the urinary excretion of other water-soluble vitamins, suggesting no effect on the metabolism of other water-soluble vitamins. The results of the food intake and body weight gain indicated that the lowest observed adverse effect level for young rats was 79.2 mg/kg body weight/day, while the no observed adverse effect level was 38.4 mg/kg/day. These results suggested immediately setting a tolerable upper intake level for biotin.
- 社団法人 日本農芸化学会の論文
- 2007-12-23
著者
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FUKUWATARI Tsutomu
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures
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SHIBATA Katsumi
Laboratory of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures
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Sawamura Hiromi
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultur
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Sawamura Hiromi
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Fukuwatari Tsutomu
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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Shibata Katsumi
Laboratories Of Food Science And Nutrition Department Of Life Style Studies School Of Human Cultures
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