Effects of Fasting on the Blood NAD Level, and Urinary Excretion of 5-Hydroxyindole-3-acetic Acid, and Nicrotinamide and Its Metabolites in Rats (Food & Nutrition)

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The effects of fasting on the blood NAD level, and the urinary excretion of tryptophan metabolites, such as 5-hydroxyindole-3-acetic acid (5-HIAA), nicotinamide, N^1-methylnicotinamide (MNA), N^1-methyl-2-pyridone-5-carboxamide (2-py) and H^1-methyl-4-pyridone-3-carboxamide (4-py), in rats were investigated. Rats, weighing about 430g, were fasted for 5days. The body weight loss during the fasting period was about 10g per day. The blood NAD levels during the fasting period did not decrease compared with the values during the feeding period. The urinary excretion of 5-HIAA abruptly decreased by about 1/2 on day 1 of fasting, compared with the value during the feeding period, and then remained constant. The level of urinary excretion of nicotinamide during the fasting period was almost the same as the value during the feeding peiod. However, the urinary excretion of nicotinamide metabolites, such as MNA, 2-py and 4-py, gradually decreased with the fasting time and the values had decreased by 1/2〜1/3 on day 3 of fasting, compared with the values during the fasting period, and then remained constant. On the basis of these findings, the tryptophan metbolism during the fasting period was discussed.
社団法人日本農芸化学会の論文
1988-09-23