Effect of Neural Blockers and CR-1392 on the Pancreatic Enzyme Secretion in Response to Soybean Trypsin Inhibitor and Hydrochloric Acid(Food & Nutrition)

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概要

• 論文の詳細を見る

• The effects of neural blockers on the pancreatic enzyme secretion in response to an intraluminal infusion of soybean trypsin inhibitor and HCl were investigated. The stimulation of pancreatic enzyme secretion upon the intraluminal infusion of soybean trypsin inhibitor was not blocked by atropine, but was completely blocked by guanethidine. The intraluminal infusion of 0.08N HCl, which is known as a potent secretagogue of secretin, caused a rapid augmentation of trypsin output, which was not blocked by atropine or guanethidine. Preinjection of CR-1392 (1.5mg/kg, i.p.), which is a strong cholecystokinin receptor antagonist, completely blocked the pancreatic response to soybean trypsin inhibitor, but not that to 0.08N HCl. This inferred that guanethidine specifically suppressed the CCK-release from the small intestine. These findings suggest that the pancreatic enzyme secretion in response to soybean trypsin inhibitor is mainly mediated by CCK, and that adrenergic modulation would be involved in the CCK-mediated pancreatic enzyme secretion in response to soybean trypsin inhibitor.

• 社団法人日本農芸化学会の論文
• 1989-09-23

著者

• Fushiki Tohru

  京都大学 農学研究科栄養化学分野

• Iwai K

  Kyoto Univ. Kyoto

• Iwai K

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Iwai Kazuo

  Laboratory Of Nutrition Chemistry Faculty Of Home Economics Kobe Women's University

• Iwai Kazuo

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Sugimoto Etsuro

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Fushiki T

  Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agri

• Fushiki Tohru

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Tsuzuki Satoshi

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Tsuzuki Satoshi

  Department Of Biochemistry Vanderbilt University School Of Medicine

• FUKUOKA Shin-ichi

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• TAKADA Misako

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• MURAYAMA Hidemichi

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• Takada Misako

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Murayama Hidemichi

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Fukuoka Shin-ichi

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

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