Intragastric Administration of TRPV1, TRPV3, TRPM8, and TRPA1 Agonists Modulates Autonomic Thermoregulation in Different Manners in Mice
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概要
- 論文の詳細を見る
The main aim of this study was to elucidate whether thermosensitive transient receptor potential channels (thermoTRPs) play a role in controlling autonomic thermoregulation. We investigated whether the activation of certain thermoTRPs, TRPV1, TRPV3, TRPM8, and TRPA1, would induce autonomic thermoregulation by administering chemical agonists derived from spices and aroma chemicals of these channels to anesthetized mice. We discovered the following: Capsaicin, a TRPV1 agonist, enhanced thermogenesis and heat diffusion; thymol and ethyl vanillin, TRPV3 agonists, did not have any effect on thermogenesis or heat diffusion; menthol and 1,8-cineole, TRPM8 agonists, enhanced thermogenesis; and allyl isothiocyanate and cinnamaldehyde, TRPA1 agonists, enhanced thermogenesis and inhibited heat diffusion. These results suggest that these thermoTRP agonists derived from spices and aroma chemicals modulate autonomic thermoregulation, except for TRPV3 agonists. Our findings suggest the possibility that each thermoTRP is a key sensor inducing reasonable autonomic thermoregulation according to its own activated temperature range.
- 社団法人 日本農芸化学会の論文
- 2009-05-23
著者
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Fushiki Tohru
Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agri
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Fushiki Tohru
京都大学 農学研究科栄養化学分野
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Fushiki Tohru
Kyoto Univ. Kyoto City Jpn
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KAWABATA Fuminori
Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Ag
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Fushiki T
Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agri
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MASAMOTO Yukiko
Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Ag
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Kawabata Fuminori
Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agri
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Fushiki Tohru
Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agri
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Fushiki Tohru
Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agri
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Fushiki Tohru
Laboratory Of Nutrition Chemistry Division Of Applied Life Sciences Graduate School Of Agriculture K
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Masamoto Yukiko
Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agri
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