Blood Lactate Functions as a Signal for Enhancing Fatty Acid Metabolism during Exercise via TGF-β in the Brain

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概要

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• Moderate-intensity running (treadmill velocity of 21 m/min) increased blood lactate and actived transforming growth factor-β (TGF-β) concentration in rat cerebrospinal fluid (CSF). On the other hand, low-intensity running (15 m/min) did not increase blood lactate and caused no change in CSF TGF-β. Intraperitoneal (i.p.) administration of lactate to anesthetized rats caused an increase in blood lactate similar to that observed after a 21 m/min running exercise and increased the level of active TGF-β in CSF. Intraperitoneal administration of lactate at the same dose to awake and unrestricted rats caused a decrease in the respiratory exchange ratio, that is, enhancement of fatty acid oxidation and depression of spontaneous motor activity (SMA). Given that intracisternal administration of TGF-β to rats has been reported to enhance fatty acid metabolism and to depress SMA, we surmise that the observed changes caused by i.p. lactate administration in this study were mediated, at least in part, by TGF-β in the brain.

著者

• Kitaoka Ryo

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Ag

• MATSUMURA Shigenobu

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Ag

• Inoue Kazuo

  Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agri

• YAMADA Hiroyuki

  Laboratory for Reproduction Engineering, Department of Animal Production, Meiji University

• Fushiki Tohru

  Laboratory Of Nutrition Chemistry Division Of Applied Life Sciences Graduate School Of Agriculture K

• Fujikawa Teppei

  Laboratory Of Nutrition Chemistry Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• IWAKI Yoko

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• FUJITANI Mina

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• SHIBAKUSA Tetsuro

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Yamada Hiroyuki

  Laboratory For Reproduction Engineering Department Of Animal Production Meiji University

• MATSUMURA Shigenobu

  Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

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