Nicotinate Phosphoribosyltransferase from Hog Liver: Regulatory Effect of ATP at a Physiological Concentrations of 5-Phosphoribosyl- 1 -pyrophosphate
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概要
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Nicotinate phosphoribosyltransferase (NPRTase, EC 2.4.2. 1 1) purified from hog liver was stimulated by orthophosphate. This stimulation was independent of ATPwhich activated this enzyme by increasing the velocity and lowering the Km values for nicotinic acid and 5- phosphoribosyl-1-pyrophosphate (PRPP). This independent stimulation by orthophosphate and activation by ATPwere true of hog liver or rat liver homogenate as well as the purified hog liver NPRTase, showing that there maybe some physiological role of these compounds in vivo. The Ka value for ATPwas about 1.2mM. At a physiological concentration of PRPP, it was mainly used by quinolinate phosphoribosyltransferase (QPRTase, EC 2.4.2.19) in the reconstituted assay conditions of NPRTase and QPRTase if the ATP concentration was lower. But if the ATP concentration was higher, PRPP was used by both QPRTase and NPRTase. Therefore, ATP was found to play a very important role for the biosynthesis of NAD via the salvage pathway.
著者
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Iwai Kazuo
Department Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Shibata Katsumi
Food And Nutrition Laboratories Teikoku Women's University
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HAYAKAWA Takashi
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University
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