Nutritional Factors Affecting the Activity of Liver Nicotinamide Methyltransferase and Urinary Excretion of N^1-Methylnicotinamide in Rats(Food & Nutrition)

概要

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The nutritional factors affecting the activity of liver nicotinamide methyltransferase (EC 2.1.1.1) and urinary excretion of N^1-methylnicotinamide in rats were investigated. Nicotinamide methyltransferase was found mainly in liver and a little activity was detected in kidney. This enzyme activity was elevated by the feeding of an excess nicotinamide-containing diet (2.0-fold), a thiamin-free diet (3.3-fold), a high protein diet (1.6-fold), and a fat-free diet (1.9-fold) compared with the activity of each control group. On the other hand, urinary excretion of N^1-methylnicotinamide was also increased by the feeding of the excess nicotinamide-containing diet (182-fold), the thiamin-free diet (1.6-fold), and the high protein diet (2.8-fold), while its excretion was decreased by the fat-free diet (0.35-fold). Therefore, urinary excretion of N^1-methylnicotinamide could be controlled by some unknown factors, possibly the nicotinamide concentration, rather than by the activity of nicotinamide methyltransferase.
社団法人日本農芸化学会の論文
1986-06-23