IL-1β production and gene expression by peptidoglycan from Lactobacillus casei in human dental pulp cells of deciduous teeth and permanent teeth
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概要
- 論文の詳細を見る
The purpose of this study was to compare the production of interleukin-1β (IL-1β) by peptidoglycan from Lactobacillus casei (L. casei) in human pulp-derived fibroblasts from deciduous (DHPF) and permanent teeth (HPF). DHPF and HPF were collected from 6 noncarious deciduous teeth (6-9 year-old individuals) and 6 noncarious permanent teeth (20-25 year old individuals) extracted in the course of orthodontic treatment. Both IL-1β protein production and IL-1β mRNA levels from peptidoglycan- treated DHPF and HPF were clearly enhanced, compared to IL-1β protein production and IL-1β mRNA levels from peptidoglycan-non-treated DHPF and HPF that were not treated by peptidoglycan. Furthermore, IL-1β protein production and IL-1β mRNA levels from peptidoglycan-treated DHPF showed clearly lower levels, compared with IL-1β protein production and IL-1β mRNA levels from peptidoglycan-treated HPF. These findings suggest that pulpitis in deciduous teeth was less induced than pulpitis in permanent teeth, and that L. casei-peptidoglycan stimulated IL-1β production through enhancement of IL-1β mRNA expression from DHPF and HPF.
- 日本大学の論文
著者
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ABIKO Yoshimitsu
Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo
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SUZUKI Yasuhiro
Department of Information Processing, Tokyo Institute of Technology
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Suzuki Yasuhiro
Department Of Pediatrics Nihon University School Dentistry At Matsudo
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Maeda Takahide
Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
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Maeda Takahide
Department Of Pediatrics Nihon University School Dentistry At Matsudo
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Abiko Yoshimitsu
Department Of Biochemistry Nihon University School Dentistry At Matsudo
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Abiko Y
Department Of Biochemistry And Molecular Biology Nihon University School Of Dentistry At Matsudo:res
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Abiko Yoshimitsu
Department Of Biochemistry And Molecular Biochemistry Nihon University School Of Dentistry At Matsud
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Matsushima Kiyoshi
Department of Endodontics, Nihon University School Dentistry at Matsudo
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Suzuki Yasuhiro
Department Of Breast And Endocrine Surgery Tokai University School Of Medicine
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Maeda Takahide
Department Of Pediatric Dentistry Nihon University Graduate School Of Dentistry At Matsudo
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Matsushima Kiyoshi
Department Of Endodontics Nihon University School Dentistry At Matsudo
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Matsushima Kiyoshi
Department Of Endodontics And Research Institute Of Oral Science Nihon University School Of Dentistr
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Matsushima Kiyoshi
Department of Endodontics
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