Expression of Platelet-Derived Growth Factor Receptor Beta in Dog Mandible by Beta-Tricalcium Phosphate

スポンサーリンク

概要

• 論文の詳細を見る

• Beta-tricalcium phosphate (β-TCP) has been used for bone regeneration with satisfactory clinical results in accelerating bone formation. However, little is known about the molecular mechanisms enhancing the bone formation by β-TCP. To understand this mechanism, β-TCP was implanted into bone defects of the mandible in beagles and gene expression profiles were examined using DNA microarray technology. β-TCP altered many gene expressions ; among those genes, a significantly higher mRNA level of platelet-derived growth factor receptor beta (PDGFRB) was observed. The enhanced PDGFRB gene expression level was successfully confirmed by reverse transcription-polymerase chain reaction and real-time polymerase chain reaction. Immunohistochemical study using antibody against PDGFRB also demonstrated that PDGFRB protein expression was enhanced by β-TCP. Because PDGFRB is a potent regulator of mesenchymal cell function of wound healing and osteogenic differentiation, the enhancement of the PDGFRB gene expression by β-TCP may be an important mechanism in accelerating bone formation.

著者

• Lee Sheng-yang

  Graduate Institute Of Oral Rehabilitation Sciences Collage Of Oral Medicine Taipei Medical Universit

• Abiko Yoshimitsu

  Department Of Biochemistry And Molecular Biochemistry Nihon University School Of Dentistry At Matsud

• Zhao Jian

  Department Of Biochemistry And Molecular Biology Nihon University School Of Dentistry At Matsudo

• Watanabe Takao

  Departmant Of Mathematics Faculty Of Science Osaka University

• Oshitani Toshiyuki

  Departments Of Biochemistry And Molecular Biology Nihon University School Of Dentistry At Matsudo

• Takahashi Tetsuji

  Department Of Biochemistry And Molecular Biology Nihon University School Of Dentistry At Matsudo

• Watanabe Takao

  Department of Oral Anatomy, Kanagawa Dental College

• Chu Cheng-Hsing

  Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo

• Oshitani Toshiyuki

  Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo

• Lee Sheng-Yang

  Graduate Institute of Oral Rehabilitation Sciences and School of Dentistry, Taipei Medical University

関連論文

• Discoidin Domain Receptor-1 Gene Expression of Osteoblasts on Fibronectin Coated Titanium Disks
• Preliminary Individualized Chemotherapy for Malignant Astrocytomas Based on O^6-Methylguanine-Deoxyribonucleic Acid Methyltransferase Methylation Analysis
• Dietary Sources of Nutrient Consumption in a Rural Japanese Population
• Connexin 43 expression at an early stage in dog mandibles by β-TCP
• Proteomic Analysis of Apoptosis Induced by Xanthoangelol, a Major Constituent of Angelica keiskei, in Neuroblastoma(Pharmacology)
• High-temperature requirement protein A1 (HtrA1) gene expression in dog mandible bone by β-TCP
• Effect of oxygen radical on apoptosis in human submandibular gland cell lines
• T Helper Cytokine Responses Elicited by Nasal Immunization with Heat-Killed Recombinant Lactobacillus casei Expressing Outer Membrane Protein of Porphyromonas gingivalis
• Immunogenicity and Protective Efficacy of Heat-Killed Recombinant Lactobacillus casei Expressing Outer Membrane Protein of Porphyromonas gingivalis
• Embryonic Development in the Eggs of the Silkworm, Bombyx mori, Exposed to the Space Environment
• Resonance Frequency Analysis for Osseointegration in Three Surgical Conditions of Dental Implants
• Large-scale preparative disk gel electrophoresis with electroosmotic medium pump system
• Comparison of Otoraplin Gene Expressions in Osteoblasts Grown on Fibronectin and GRGDSP Peptide-Coated Titanium Disks
• Identification of Reduced Fibronectin 1 Gene Expression in Osteoblasts following Hydrogen Peroxide Treatment using Subtractive Gene Cloning
• Quantitative Spectroscopic Analysis of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Intensity in Diffusely Infiltrating Astrocytomas
• TrkA expression is associated with an elevated level of apoptosis in classic medulloblastomas
• Metastatic Pituitary Tumor From Renal Cell Carcinoma Treated by Fractionated Stereotactic Radiotherapy : Case Report
• SURGICAL TREATMENT FOR RECURRENT MALIGNANT ASTROCYTOMA : OPERATIVE INDICATIONS AND NEUROIMAGING STUDY
• Construction of a Chimeric Shuttle Plasmid via a Heterodimer System : Secretion of an scFv Protein from Bacillus brevis Cells Capable of Inhibiting Hemagglutination
• Gene expression monitoring in osteoblasts on titanium coated with fibronectin-derived peptide
• Further genetic studies on the Katsunuma population of Drosophila melanogaster
• Bentall Operation, Total Aortic Replacement and Mitral Valve Replacement for a Young Adult with Marfan Syndrome : A Case of Three-Staged Operation
• Helicobacter pylori Seroprevalence in Patients with Mild Asthma
• Expression of Platelet-Derived Growth Factor Receptor Beta in Dog Mandible by Beta-Tricalcium Phosphate
• Cytogenetic mapping of the Lethal hybrid rescue gene of Drosophila simulans
• Type I Collagen Grafting on Titanium Surfaces Using Low-temperature Glow Discharge
• Purification and Characterization of an Oligo-isomaltosaccharide Synthase from a Streptococcus sobrinus Glucosyltransferase-I Deficient Mutant
• Aberrant Hypermethylation of Non-Promoter Zygote Arrest 1 (Zar1) in Human Brain Tumors
• Optimum Culture Conditions for Production of Exfoliative Toxin by Staphylococcus hyicus
• 6. Low-energy laser irradiation stimulates bone formatioun via IGF-I expression in fetal rat calvarial cells.
• IL-1β production and gene expression by peptidoglycan from Lactobacillus casei in human dental pulp cells of deciduous teeth and permanent teeth
• Determination of Short Peptide in a Porphyromonas gingivalis Protein Antigen Recognized by Sera from Periodontitis Patients
• The relationship between premature ageing and immune responses in the oral cavity of Down syndrome
• A Fusion Protein of the Hemagglutinin A Antigenic Region of Porphyromonas gingivalis and Maltose-Binding Protein Induces Antibody Responses in the Oral Cavity
• Oxidative stress induces phosphorylation of the ABC transporter, ATP-binding protein, in Porphyromonas gingivalis
• Gene Cloning and Characterization of Short Immunodominant Hemagglutinin A of Porphyromonas gingivalis
• Reduction of Early Growth Response-1 Gene Expression in Osteoblasts by Hydrogen Peroxide
• A Newly Designed Resonance Frequency Analysis Device for Dental Implant Stability Detection
• Finite element analysis of thermo-debonding mechanism in dentin bonding systems
• COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 12)EFFECTS OF CYCLOPHOSPHAMIDE ON SPERMATOGENESIS
• Gene Expression of MC3T3-E1 Cells on Fibronectin-immobilized Titanium Using Tresyl Chloride Activation Technique
• Transcutaneous Immunization with P. gingivalis Surface Protein Antigen Induces T Helper 2 Responses in Systemic Tissues
• Nasal Immunization with P. gingivalis Surface Protein Antigen and Cholera Toxin Adjuvant Induces T Helper 2 Responses in Both Mucosal and Systemic Compartments
• Synthetic Studies on d-Biotin, Part 9 : An Improved Asymmetric Synthetic Route to d-Biotin via Hoffmann-Roche Lactone-Thiolactone Approach
• Salt-Adaptation of Tobacco BY2 Cells Induces Change in Glycoform of N-Glycans : Enhancement of Exo- and Endo-Glycosidase Activities by Salt-Adaptation
• Aggregatibacter actinomycetemcomitans Leads to Endothelial Apoptosis and Atherosclerosis Development in Spontaneously Hyperlipidemic Mice
• Functional Analysis of the Thioredoxin Domain in Porphyromonas gingivalis HBP35
• Identification of Inhibin B Gene Expression in Osteoblast by Low Level Laser Irradiation
• Identification of the functional domain in a coaggregation factor from Porphyromonas gingivalis
• Connexin 43 expression at an early stage in dog mandibles by β-TCP
• Reduction of Bone Nodule Formation in MC3T3-E1 Cells by Treatment with Hydrogen Peroxide
• Isolated Intracranial Rosai-Dorfman Disease Without Dural Attachment : Case Report
• Promoter and Terminator Analysis of 40-kDa Outer Membrane Gene (hbp35) in Porphyromonas gingivalis 381
• Effect of TNF-α on uPA and uPA receptor expressions human gingival fibroblasts
• Effect of Low Level Laser Irradiation on CXCR3 Gene Expression in Rheumatoid Arthritis Joint
• Effect of Low-Level Laser Irradiation on CXCL13 Gene Expression in Rheumatoid Arthritis Rat Joints
• A note on the mean value theorem for special homogeneous spaces
• Hydrogen Peroxide Reduced Osteomodulin Gene Expression in MC3T3-E1
• Osteomodulin Gene Expression in Beagle Dog Mandible by Beta-Tricalcium Phosphate
• Age-related changes in IGF-1 expression in submandibular glands of senescence-accelerated mice
• Profiling of differentially expressed genes in human gingival epithelial cells and fibroblasts by DNA microarray
• Fundamental Hermite constants of linear algebraic groups
• Residual automorphic representations of Sp_4
• Global Theta Liftings of General Linear Groups
• The local theta correspondence of irreducible type 2 dual reductive pairs
• Dietary Sources of Nutrient Consumption in a Rural Japanese Population.
• Reduction of Matrix Metalloproteinase-3 Expression in Rheumatoid Arthritis Rat Joints by Light-emitting Diode
• Stimulation of Mesenchymal-epithelial Transition Factor (c-Met) Expression in Candida Albicans-infected Human Gingival Epithelial Cells and Rat Gingival Epithelium
• Short-Pulse Intrinsic Tunneling Spectroscopy in Bi2Sr2CaCu2O8+\delta under Suppressed Self Heating
• Fibroblast growth factor 2 and forskolin induce mineralization-associated genes in two kinds of osteoblast-like cells
• Nasal Vaccination with a Fusion Protein of Hemagglutinin A Antigenic Region and Maltose-Binding Protein Elicits CD4+ T Cell Responses via Toll-Like Receptor 4
• High-Temperature Requirement Protein A1 (HtrA1) Gene Expression in Dog Mandible Bone by β-TCP
• Fabrication of Small Mesa Structures of Bi2Sr2CaCu2O8+δ Intrinsic Josephson Junctions Using Polyimide Process: Improvement of Current–Voltage Characteristics with a Very Small Number of Junctions
• Gene Expression Profiling during Growth in vitro Using a Custom-made Porphyromonas gingivalis Gene Array
• Differentiation of the human mesenchymal stem cells derived from bone marrow and enhancement of cell attachment by fibronectin
• Analysis of mRNA Expression in Epithelial Layers of Oral Lichen Planus by Laser Microdissection with RT-PCR
• Monitoring of dnaK gene expression in Porphyromonas gingivalis by oxygen stress using DNA microarray
• Attachment Activity of RGD-Motif Peptides to Osteoblast-Like Cell Line MC3T3-E1
• Osteomodulin Gene Expression in Human Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblastic Differentiation
• Signal Peptide Analyses and Localization of 40-kDa Outer Membrane Protein in Porphyromonas gingivalis 381
• Inhibition of Porphyromonas gingivalis hemagglutinating activity by IgY against a truncated HagA
• Retraction : Promoter and Terminator Analysis of 40-kDa Outer Membrane Gene (hbp35) in Porphyromonas gingivalis 381
• Sustained virological response of patients with hepatitis C virus genotype 2 depends on pegylated interferon compliance

もっと見る 閉じる

スポンサーリンク